Päivi Koskinen
PhD, Adj. prof.
paivi.koskinen@utu.fi +358 29 450 4218 +358 50 434 0905 Vesilinnantie 5 Turku : Room 130 : https://orcid.org/0000-0002-6864-4457(external) |
Cell signalling; Molecular Genetics; Protein kinases; Metastatic growth of cancer cells; Chemosensation; Environmental biomonitoring; C. elegans nematodes
I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.
The research in my group is currently divided into three major projects:
1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.
2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.
3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.
As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.
- Developmental expression of Pim kinases suggests functions also outside of the hematopoietic system (2000)
- Oncogene
- Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2R alpha, c-myc, and pim-1 genes in human T cells (1999)
- Blood
- IFN-alpha activates multiple STAT proteins and upregulates proliferation associated IL-2R-alpha, c-myc, and pim-1 genes in human T cells. (1998)
- European Cytokine Network
- Pim-1 kinase and p100 cooperate to enhance c-myb activity (1998)
- Molecular Cell
- DETERMINATION OF SEQUENCES RESPONSIBLE FOR THE DIFFERENTIAL REGULATION OF MYC FUNCTION BY DELTA-MAX AND MAX (1995)
- Oncogene
- MAD3 AND MAD4 - NOVEL MAX-INTERACTING TRANSCRIPTIONAL REPRESSORS THAT SUPPRESS C-MYC DEPENDENT TRANSFORMATION AND ARE EXPRESSED DURING NEURAL AND EPIDERMAL DIFFERENTIATION (1995)
- EMBO Journal
- REPRESSION OF MYC-RAS COTRANSFORMATION BY MAD IS MEDIATED BY MULTIPLE PROTEIN-PROTEIN INTERACTIONS (1995)
- CELL GROWTH & DIFFERENTIATION
- MAX ACTIVITY IS AFFECTED BY PHOSPHORYLATION AT 2 NH2-TERMINAL SITES (1994)
- CELL GROWTH & DIFFERENTIATION
- MYC PROTEIN - PARTNERS AND ANTAGONISTS (1994)
- Critical Review in Oncogenesis
- ALTERNATIVE MESSENGER-RNA FORMS AND OPEN READING FRAMES OF THE MAX GENE (VOL 8, PG 503, 1993) (1993)
- Oncogene
- A SUB-SET OF IMMEDIATE-EARLY MESSENGER-RNAS INDUCED BY TUMOR-NECROSIS-FACTOR-ALPHA DURING CELLULAR CYTOTOXIC AND NONCYTOTOXIC RESPONSES (1993)
- International Journal of Cancer
- MYC AMPLIFICATION - REGULATION OF MYC FUNCTION (1993) KOSKINEN PJ, MAKELA TP, VASTRIK I, ALITALO K