Päivi Koskinen
PhD, Adj. prof.
paivi.koskinen@utu.fi +358 29 450 4218 +358 50 434 0905 Vesilinnantie 5 Turku Office: Room 130 ORCID identifier: https://orcid.org/0000-0002-6864-4457 |
Cell signalling; Molecular Genetics; Protein kinases; Metastatic growth of cancer cells; Chemosensation; Environmental biomonitoring; C. elegans nematodes
I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.
The research in my group is currently divided into three major projects:
1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.
2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.
3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.
As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.
- Biomonitoring of Indoor Air Fungal or Chemical Toxins with Caenorhabditis elegans nematodesHomogeneous peptide-break assay for luminescent detection of enzymatic protein post-translational modification activity utilizing charged peptidesPim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts (2023)
- PathogensPLoS ONE
(A1 Refereed original research article in a scientific journal) - (2023)
- FEBS JournalAnalytica Chimica Acta
(A1 Refereed original research article in a scientific journal) - Expression and ERG regulation of PIM kinases in prostate cancer2021
- Cancer Medicine
- PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion2021
- Journal of Biological ChemistryOrganic Letters
(A1 Refereed original research article in a scientific journal) - PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB12021
- Cell Communication and Signaling
(A1 Refereed original research article in a scientific journal) - Critical evaluation of the subcutaneous engraftments of hormone naïve primary prostate cancer2020
- Translational andrology and urologyDuodecimInternational Journal of Biochemistry and Cell Biology
(A1 Refereed original research article in a scientific journal) - PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteinsNucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones (2020)
- Cell Communication and Signaling
(A1 Refereed original research article in a scientific journal) - PIM-kinaasit syövän etenemisen edistäjinä ja lääkekehityskohteina (2019)
(A1 Refereed original research article in a scientific journal) - (2019)
- Cell Communication and Signaling
(A1 Refereed original research article in a scientific journal) - PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans (2019)
- eNeuro
(A1 Refereed original research article in a scientific journal) - (2019) Sisäilmastoseminaari 2019 Sari Paavanen-Huhtala, Maria A Andersson, Päivi J Koskinen
(D3 Article in a professional conference publication) - (2018) Sisäilmastoseminaari 2018 Sari Paavanen-Huhtala, Karuna Kalichamy, Anna-Mari Pessi, Sirkku Häkkilä, Annika
Saarto, Raimo Mikkola, Maria A. Andersson, Päivi J. Koskinen
(D3 Article in a professional conference publication) - (2018)
(A2 Refereed review article in a scientific journal ) - (2017)
(A1 Refereed original research article in a scientific journal) - PIM kinases: From survival factors to regulators of cell motilitySukkulamadot sisäilmaongelmien bioindikaattoreina (2017)
(A2 Refereed review article in a scientific journal ) - Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells (2017) Sisäilmastoseminaari 2017 Sari Paavanen-Huhtala, Karuna Kalichamy, Sirkku Häkkilä, Anna-Mari Pessi, Annika Saarto, Päivi Koskinen
(D3 Article in a professional conference publication) - (2016)
- Oncotarget
(A1 Refereed original research article in a scientific journal) - The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways (2016)
- Experimental Cell Research
(A1 Refereed original research article in a scientific journal) - Pim kinases and Pim inhibitors in the regulation of prostate cancer cell migration and invasion (2015)
- Cancer Research
(Other publication) - (2015)
(A1 Refereed original research article in a scientific journal)