Päivi Koskinen
PhD, Adj. prof.
paivi.koskinen@utu.fi +358 29 450 4218 +358 50 434 0905 Vesilinnantie 5 Turku : Room 130 : https://orcid.org/0000-0002-6864-4457(external) |
Cell signalling; Molecular Genetics; Protein kinases; Metastatic growth of cancer cells; Chemosensation; Environmental biomonitoring; C. elegans nematodes
I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.
The research in my group is currently divided into three major projects:
1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.
2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.
3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.
As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.
- Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas (2013)
- Oncogene
- Proviral Integration Site for Moloney Murine Leukemia Virus (PIM) Kinases Promote Human T Helper 1 Cell Differentiation (2013)
- Journal of Biological Chemistry
- Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells (2013)
- PLoS ONE
- Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors (2012)
- European Journal of Medicinal Chemistry
- DEVELOPMENT OF KINASE-SELECTIVE INHIBITORS: CHALLENGES WITH PIM KINASES (2011)
- European Journal of Pharmaceutical Sciences
- Enrichment and sequencing of phosphopeptides on indium tin oxide coated glass slides (2011)
- Molecular BioSystems
- Data combination from multiple matrix-assisted laser desorption/ionization (MALDI) matrices: opportunities and limitations for MALDI analysis (2010)
- Rapid Communications in Mass Spectrometry
- Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion (2010)
- Molecular Cancer
- KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA (2009)
- PLoS Pathogens
- Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor (2009)
- Neoplasia
- Oncogenic Pim family kinases as potential drug targets (2007)
- Scandinavian Journal of Immunology
- Oncogenic Pim family kinases as potential drug targets (2006)
- European Journal of Pharmaceutical Sciences
- Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity (2006)
- BMC Cell Biology
- Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation. (2005)
- Immunology
- Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells (2005)
- Molecular Brain Research
- Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity (2005)
- Virology
- Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3 (2004)
- Blood
- Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser(112) gatekeeper site (2004)
- FEBS Letters
- Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1 (2003)
- Laboratory Investigation
- Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase (2002)
- Journal of Immunology