Päivi Koskinen
PhD, Adj. prof.
paivi.koskinen@utu.fi +358 29 450 4218 +358 50 434 0905 Vesilinnantie 5 Turku Office: Room 130 ORCID identifier: https://orcid.org/0000-0002-6864-4457 |
Cell signalling; Molecular Genetics; Protein kinases; Metastatic growth of cancer cells; Chemosensation; Environmental biomonitoring; C. elegans nematodes
I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.
The research in my group is currently divided into three major projects:
1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.
2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.
3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.
As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.
- (2007)
- Scandinavian Journal of Immunology
(A4 Refereed article in a conference publication ) - (2006)
- European Journal of Pharmaceutical SciencesVirology
(A4 Refereed article in a conference publication ) - Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity (2006)
- BMC Cell BiologyMolecular Brain ResearchLaboratory Investigation
(A1 Refereed original research article in a scientific journal) - Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation. (2005)
- ImmunologyBlood
(A1 Refereed original research article in a scientific journal) - Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells (2005)
(A1 Refereed original research article in a scientific journal) - Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity (2005)
(A1 Refereed original research article in a scientific journal) - Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3 (2004)
(A1 Refereed original research article in a scientific journal) - Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser(112) gatekeeper site (2004)
- FEBS Letters
(A1 Refereed original research article in a scientific journal) - Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1 (2003)
(A1 Refereed original research article in a scientific journal) - The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death (2003)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal)



