A1 Refereed original research article in a scientific journal
Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells
Authors: Glazova M, Aho TLT, Palmetshofer A, Murashov A, Scheinin M, Koskinen PJ
Publisher: ELSEVIER SCIENCE BV
Publication year: 2005
Journal: Molecular Brain Research
Journal name in source: MOLECULAR BRAIN RESEARCH
Journal acronym: MOL BRAIN RES
Volume: 138
Issue: 2
First page : 116
Last page: 123
Number of pages: 8
ISSN: 0169-328X
DOI: https://doi.org/10.1016/j.molbrainres.2005.04.003
Abstract
The activity of NFAR family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim-1 serine/threonine kinase. Here, we demonstrate that NFATc-dependent transcription is inducible also in NGF-differentiated rat PC12 pheochromocytoma cells treated with phorbol esthers, calcium ionophores and/or forskolin and that the Pim-1 kinase can further potentiate the effects of these agents. PC 12 cells, share many characteristics with sympathetic neurons and can be induced to produce and release catecholamines, such as dopamine and noradrenaline, and inflammatory cytokines, such as interleukin 6. Interestingly, Pim-1 can synergize with forskolin-induced signaling pathways to stimulate also neuroendocrine functions of PC12 cells. (c) 2005 Elsevier B.V. All rights reserved.
The activity of NFAR family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim-1 serine/threonine kinase. Here, we demonstrate that NFATc-dependent transcription is inducible also in NGF-differentiated rat PC12 pheochromocytoma cells treated with phorbol esthers, calcium ionophores and/or forskolin and that the Pim-1 kinase can further potentiate the effects of these agents. PC 12 cells, share many characteristics with sympathetic neurons and can be induced to produce and release catecholamines, such as dopamine and noradrenaline, and inflammatory cytokines, such as interleukin 6. Interestingly, Pim-1 can synergize with forskolin-induced signaling pathways to stimulate also neuroendocrine functions of PC12 cells. (c) 2005 Elsevier B.V. All rights reserved.
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