A1 Refereed original research article in a scientific journal
Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts
Authors: Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Harkonen P, Koskinen PJ
Publisher: PUBLIC LIBRARY SCIENCE
Publication year: 2015
Journal: PLoS ONE
Journal name in source: PLOS ONE
Journal acronym: PLOS ONE
Article number: ARTN e0130340
Volume: 10
Issue: 6
Number of pages: 20
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0130340
Our results indicate that Pim overexpression enhances the invasive properties of prostate cancer cells in vivo. These effects can be reduced by the Pim-selective inhibitor DHPCC-9, which can reach tumor tissues without serious side effects. Thus, Pim-targeting therapies with DHPCC-9-like compounds may help to prevent progression of local prostate carcinomas to fatally metastatic malignancies.
