Päivi Koskinen
PhD, Adj. prof.
paivi.koskinen@utu.fi +358 29 450 4218 +358 50 434 0905 Vesilinnantie 5 Turku Office: Room 130 ORCID identifier: https://orcid.org/0000-0002-6864-4457 |
Cell signalling; Molecular Genetics; Protein kinases; Metastatic growth of cancer cells; Chemosensation; Environmental biomonitoring; C. elegans nematodes
I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.
The research in my group is currently divided into three major projects:
1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.
2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.
3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.
As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.
- Biomonitoring of Indoor Air Fungal or Chemical Toxins with Caenorhabditis elegans nematodes (2023)
- Pathogens
(Refereed journal article or data article (A1)) - PIM kinases phosphorylate lactate dehydrogenase A at serine 161 and suppress its nuclear ubiquitination (2022)
- FEBS Journal
(Refereed journal article or data article (A1)) - Expression and ERG regulation of PIM kinases in prostate cancer (2021)
- Cancer Medicine
(Refereed journal article or data article (A1)) - PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion (2021)
- Journal of Biological Chemistry
(Refereed journal article or data article (A1)) - PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1 (2021)
- Cell Communication and Signaling
(Refereed journal article or data article (A1)) - Critical evaluation of the subcutaneous engraftments of hormone naïve primary prostate cancer (2020)
- Translational andrology and urology
(Refereed journal article or data article (A1)) - PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins (2020)
- Cell Communication and Signaling
(Refereed journal article or data article (A1)) - Homogeneous peptide-break assay for luminescent detection of enzymatic protein post-translational modification activity utilizing charged peptides (2019)
- Analytica Chimica Acta
(Refereed journal article or data article (A1)) - Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion (2019)
- Cell Communication and Signaling
(Refereed journal article or data article (A1)) - PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans (2019)
- eNeuro
(Refereed journal article or data article (A1)) - Terveydelle haitallisten sisäilman kemikaalien biomonitorointi sukkulamatojen avulla (2019) Sisäilmastoseminaari 2019 Sari Paavanen-Huhtala, Maria A Andersson, Päivi J Koskinen
(Professional conference proceedings (D3)) - Mikrobien tuottamien toksiinien biomonitorointi sukkulamatojen avulla (2018) Sisäilmastoseminaari 2018 Sari Paavanen-Huhtala, Karuna Kalichamy, Anna-Mari Pessi, Sirkku Häkkilä, Annika
Saarto, Raimo Mikkola, Maria A. Andersson, Päivi J. Koskinen
(Professional conference proceedings (D3)) - PIM-kinaasit syövän etenemisen edistäjinä ja lääkekehityskohteina (2018)
- Duodecim
(Refereed review article in scientific journal (A2)) - Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones (2017)
- Organic Letters
(Refereed journal article or data article (A1)) - PIM kinases: From survival factors to regulators of cell motility (2017)
- International Journal of Biochemistry and Cell Biology
(Refereed review article in scientific journal (A2)) - Sukkulamadot sisäilmaongelmien bioindikaattoreina (2017) Sisäilmastoseminaari 2017 Sari Paavanen-Huhtala, Karuna Kalichamy, Sirkku Häkkilä, Anna-Mari Pessi, Annika Saarto, Päivi Koskinen
(Professional conference proceedings (D3)) - Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells (2016)
- Oncotarget
(Refereed journal article or data article (A1)) - The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways (2016)
- Experimental Cell Research
(Refereed journal article or data article (A1)) - Pim kinases and Pim inhibitors in the regulation of prostate cancer cell migration and invasion (2015)
- Cancer Research
(Other (O2)) - Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts (2015)
- PLoS ONE
(Refereed journal article or data article (A1))