Jeroen Pouwels - UTU Research Portal

Jeroen Pouwels

- Docent,
Institute of Biomedicine (Faculty of Medicine)

jeroen.pouwels@utu.fi

+358 29 450 3786

Tykistökatu 6

Turku

Publications

Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype (2022)
- Molecular Cancer Therapeutics
Cvrljevic Anna N., Butt Umar, Huhtinen Kaisa, Grönroos Tove J., Böckelman Camilla, Lassus Heini, Butzow Ralf, Haglund Caj, Kaipio Katja, Arsiola Tiina, Laajala Teemu D., Connolly Denise C, Ristimäki Ari, Carpen Olli, Pouwels Jeroen, Westermarck Jukka
(A1 Refereed original research article in a scientific journal)
SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis (2022)
- Journal of Cell Science
Butt Umar, Khan Meraj H, Pouwels Jeroen, Westermarck Jukka
(A1 Refereed original research article in a scientific journal)
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice (2017)
- PLoS ONE
Peuhu E, Salomaa SI, De Franceschi N, Potter CS, Sundberg JP, Pouwels J
(A1 Refereed original research article in a scientific journal)
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex (2017)
- Journal of Cell Science
Meraj H. Khan, Siiri I. Salomaa, Guillaume Jacquemet, Umar Butt, Mitro Miihkinen, Takahiro Deguchi, Elena Kremneva, Pekka Lappalainen, Martin J. Humphries, Jeroen Pouwels
(A1 Refereed original research article in a scientific journal)
Phosphorylation of Sharpin acts as a molecular switch to control Linear Ubiquitination Assembly Complex (LUBAC) and Arp2/3 function (2016)
- Molecular Biology of the Cell
Butt U, Khan MH, Jacquemet G, Humphries MJ, Pouwels J
(Other publication)
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 (2016)
- Nature Structural and Molecular Biology
De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J
(A1 Refereed original research article in a scientific journal)
Formin-like 2 Promotes beta 1-Integrin Trafficking and Invasive Motility Downstream of PKC alpha (2015)
- Developmental Cell
Wang Y, Arjonen A, Pouwels J, Ta HS, Pausch P, Bange G, Engel U, Pan XY, Fackler OT, Ivaska J, Grosse R
(A1 Refereed original research article in a scientific journal)
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling (2015)
- PLoS ONE
Nicola De Franceschi, Emilia Peuhu, Maddy Parsons, Sami Rissanen, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska, Jeroen Pouwels
(A1 Refereed original research article in a scientific journal)
A ZO-1/alpha 5 beta 1-Integrin Complex Regulates Cytokinesis Downstream of PKC epsilon in NCI-H460 Cells Plated on Fibronectin (2013)
- PLoS ONE
Hamalisto S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H, Ivaska J
(A1 Refereed original research article in a scientific journal)
Integrin inactivators: balancing cellular functions in vitro and in vivo (2013)
- Nature Reviews Molecular Cell Biology
Bouvard D, Pouwels J, De Franceschi N, Ivaska J
(A2 Refereed review article in a scientific journal )
Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases (2013)
- Carcinogenesis
Salmela AL, Pouwels J, Maki-Jouppila J, Kohonen P, Toivonen P, Kallio L, Kallio M
(A1 Refereed original research article in a scientific journal)
SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes (2013)
- Cell Reports
Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J
(A1 Refereed original research article in a scientific journal)
Negative regulators of integrin activity (2012)
- Journal of Cell Science
Pouwels J, Nevo J, Pellinen T, Ylanne J, Ivaska J
(A2 Refereed review article in a scientific journal )
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis (2012)
- Experimental Cell Research
Salmela AL, Pouwels J, Kukkonen-Macchi A, Waris S, Toivonen P, Jaakkola K, Maki-Jouppila J, Kallio L, Kallio MJ
(A1 Refereed original research article in a scientific journal)
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint (2011)
- Carcinogenesis
Niittymaki I, Gylfe A, Laine L, Laakso M, Lehtonen HJ, Kondelin J, Tolvanen J, Nousiainen K, Pouwels J, Jarvinen H, Nuorva K, Mecklin JP, Makinen M, Ristimaki A, Orntoft TF, Hautaniemi S, Karhu A, Kallio MJ, Aaltonen LA
(A1 Refereed original research article in a scientific journal)
Loss of p38 gamma MAPK induces pleiotropic mitotic defects and massive cell death (2011)
- Journal of Cell Science
Kukkonen-Macchi A, Sicora O, Kaczynska K, Oetken-Lindholm C, Pouwels J, Laine L, Kallio MJ
(A1 Refereed original research article in a scientific journal)
SHARPIN is an endogenous inhibitor of beta 1-integrin activation (2011)
- Nature Cell Biology
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J
(A1 Refereed original research article in a scientific journal)
Spatio-temporal composition of the mitotic Chromosomal Passenger Complex detected using in situ proximity ligation assay (2011)
- Molecular Oncology
Vuoriluoto M, Laine LJ, Saviranta P, Pouwels J, Kallio MJ
(A1 Refereed original research article in a scientific journal)