A2 Refereed review article in a scientific journal
Integrin inactivators: balancing cellular functions in vitro and in vivo
Authors: Bouvard D, Pouwels J, De Franceschi N, Ivaska J
Publisher: NATURE PUBLISHING GROUP
Publication year: 2013
Journal: Nature Reviews Molecular Cell Biology
Journal name in source: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Journal acronym: NAT REV MOL CELL BIO
Number in series: 7
Volume: 14
Issue: 7
First page : 430
Last page: 442
Number of pages: 13
ISSN: 1471-0072
DOI: https://doi.org/10.1038/nrm3599
Abstract
Integrins mediate cell-matrix and cell-cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated by their activity switching such that intracellular proteins interacting with the integrin cytoplasmic domains increase or decrease integrin-ligand binding affinity. It is widely accepted that integrin activation by specific proteins is essential for cell adhesion and integrin linkage to the actin cytoskeleton. However, there is also increasing evidence that integrin-inactivating proteins are crucial for appropriate integrin function in vitro and in vivo and that the regulation of integrin-ligand interactions is a fine-tuned balancing act between inactivation and activation.
Integrins mediate cell-matrix and cell-cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated by their activity switching such that intracellular proteins interacting with the integrin cytoplasmic domains increase or decrease integrin-ligand binding affinity. It is widely accepted that integrin activation by specific proteins is essential for cell adhesion and integrin linkage to the actin cytoskeleton. However, there is also increasing evidence that integrin-inactivating proteins are crucial for appropriate integrin function in vitro and in vivo and that the regulation of integrin-ligand interactions is a fine-tuned balancing act between inactivation and activation.
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