Pirkko Heikinheimo

- Docent,
Faculty of Science (University of Turku)

Department of Biochemistry and Turun Normaalikoulu

pirkko.heikinheimo@utu.fi

Tykistökatu 6

Turku

Office: B205

Publications

1 of 2

2015
- Human MutationActa Crystallographica Section D: Biological Crystallography
Stensland HMFR, Frantzen G, Kuokkanen E, Buvang EK, Klenow HB, Heikinheimo P, Malm D, Nilssen O
(A1 Refereed original research article in a scientific journal)
Is the Bovine lysosomal phospholipase B like protein an amidase? (2014)
- Proteins
Heidi Repo, Elina Kuokkanen, Esko Oksanen, Adrian Goldman, Pirkko Heikinheimo
(A1 Refereed original research article in a scientific journal)
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation (2013)
- Diabetes
Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu SM, Boehnke M, Urano F, Collins FS, Laakso M
(A1 Refereed original research article in a scientific journal)
A monomeric TIM-barrel structure from Pyrococcus furiosus is optimized for extreme temperatures (2012)
Repo H, Oeemig JS, Djupsjobacka J, Iwai H, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Systematic Structure-Activity Study on Potential Chaperone Lead Compounds for Acid alpha-Glucosidase (2012)
- ChemMedChem
Bruckmann C, Repo H, Kuokkanen E, Xhaard H, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Molecular and cellular characterization of novel alpha-mannosidosis mutations (2011)
- Human Molecular Genetics
Kuokkanen E, Stensland HMFR, Smith W, Buvang EK, Nguyen L, Nilssen Ø, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway (2011)
- Glycobiology
Bernon C, Carre Y, Kuokkanen E, Slomianny MC, Mir AM, Krzewinski F, Cacan R, Heikinheimo P, Morelle W, Michalski JC, Foulquier F, Duvet S
(A1 Refereed original research article in a scientific journal)
Coordination sphere of the third metal site is essential to the activity and metal selectivity of alkaline phosphatases (2010)
- Protein Science
Koutsioulis D, Lyskowski A, Mäki S, Guthrie E, Feller G, Bouriotis V, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
A complete structural description of the catalytic cycle of yeast pyrophosphatase (2007) Oksanen E, Ahonen AK, Tuominen H, Tuominen V, Lahti R, Goldman A, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
(2007)
- Glycobiology
Elina Kuokkanen, Wesley Smith, Marika Mäkinen, Heidi Tuominen, Maija Puhka, Eija Jokitalo, Ole-Kristian Tollersrud, Rene Cacan, Sandrine Duvet, Thomas Berg, Pirkko Heikinheimo
(A1 Refereed original research article in a scientific journal)
Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffractionThe R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications2004
- Acta Crystallographica Section D: Biological Crystallography
Tuominen VU, Myles DAA, Dauvergne MT, Lahti R, Heikinheimo P, Goldman A
(A1 Refereed original research article in a scientific journal)
(2002)
- American Journal of Human Genetics
Conference proceedings Stensland HMFR, Hansen GM, Heikinheimo P, Tollersrud OK, Nilssen Ø
(A4 Refereed article in a conference publication )
Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase (2001) Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A
(A1 Refereed original research article in a scientific journal)
(1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
Structural and functional consequences of substitutions at the tyrosine 55 lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphataseA site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase - Functional conservation of the active site of soluble inorganic pyrophosphatases (1997) Fabrichniy IP, Kasho VN, Hyytia T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA
(A1 Refereed original research article in a scientific journal)
The three metal ion mechanism of inorganic pyrophosphatases (1997)
- Protein EngineeringStructure
Heikinheimo P, Tuominen V, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
(1996)
- European Journal of Biochemistry
Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, Lahti R
(A1 Refereed original research article in a scientific journal)
The structural basis for pyrophosphatase catalysis (1996)
Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases (1995)
- Acta Crystallographica Section D: Biological Crystallography
HEIKINHEIMO P, SALMINEN T, LAHTI R, COOPERMAN B, GOLDMAN A
(A1 Refereed original research article in a scientific journal)
Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.
(A1 Refereed original research article in a scientific journal)