Pirkko Heikinheimo

- Teacher,
Department of Teacher Education (Turku) (Department of Teacher Education)
- Docent,
Faculty of Science (University of Turku)

Department of Biochemistry and Turun Normaalikoulu

pirkko.heikinheimo@utu.fi

Tykistökatu 6

Turku

Office: B205

Publications

1 of 2

amamutdb.no: A Relational Database for MAN2B1 Allelic Variants that Compiles Genotypes, Clinical Phenotypes, and Biochemical and Structural Data of Mutant MAN2B1 in -Mannosidosis (2015)
- Human Mutation
Stensland HMFR, Frantzen G, Kuokkanen E, Buvang EK, Klenow HB, Heikinheimo P, Malm D, Nilssen O
(A1 Refereed original research article in a scientific journal)
Is the Bovine lysosomal phospholipase B like protein an amidase? (2014)
- ProteinsGlycobiology
Heidi Repo, Elina Kuokkanen, Esko Oksanen, Adrian Goldman, Pirkko Heikinheimo
(A1 Refereed original research article in a scientific journal)
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 MutationCoordination sphere of the third metal site is essential to the activity and metal selectivity of alkaline phosphatases (2013)
- DiabetesProtein Science
Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu SM, Boehnke M, Urano F, Collins FS, Laakso M
(A1 Refereed original research article in a scientific journal)
A monomeric TIM-barrel structure from Pyrococcus furiosus is optimized for extreme temperatures (2012)
- Acta Crystallographica Section D: Biological Crystallography
Repo H, Oeemig JS, Djupsjobacka J, Iwai H, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Systematic Structure-Activity Study on Potential Chaperone Lead Compounds for Acid alpha-Glucosidase (2012)
- ChemMedChemGlycobiology
Bruckmann C, Repo H, Kuokkanen E, Xhaard H, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Molecular and cellular characterization of novel alpha-mannosidosis mutationsProduction and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction (2011)
- Human Molecular GeneticsActa Crystallographica Section D: Biological Crystallography
Kuokkanen E, Stensland HMFR, Smith W, Buvang EK, Nguyen L, Nilssen Ø, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathwayFunctional and structural characterization of disease-causing mutations in alpha-mannosidosis. (2011)
Bernon C, Carre Y, Kuokkanen E, Slomianny MC, Mir AM, Krzewinski F, Cacan R, Heikinheimo P, Morelle W, Michalski JC, Foulquier F, Duvet S
(A1 Refereed original research article in a scientific journal)
Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase (2010)
Koutsioulis D, Lyskowski A, Mäki S, Guthrie E, Feller G, Bouriotis V, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
A complete structural description of the catalytic cycle of yeast pyrophosphataseThe R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (2007) Oksanen E, Ahonen AK, Tuominen H, Tuominen V, Lahti R, Goldman A, Heikinheimo P
(A1 Refereed original research article in a scientific journal)
Characterisation and subcellular localisation of human neutral class II alfa-mannosidase (2007)
Elina Kuokkanen, Wesley Smith, Marika Mäkinen, Heidi Tuominen, Maija Puhka, Eija Jokitalo, Ole-Kristian Tollersrud, Rene Cacan, Sandrine Duvet, Thomas Berg, Pirkko Heikinheimo
(A1 Refereed original research article in a scientific journal)
(2004)
Tuominen VU, Myles DAA, Dauvergne MT, Lahti R, Heikinheimo P, Goldman A
(A1 Refereed original research article in a scientific journal)
(2002)
- American Journal of Human Genetics
Conference proceedings Stensland HMFR, Hansen GM, Heikinheimo P, Tollersrud OK, Nilssen Ø
(A4 Refereed article in a conference publication )
(2001) Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A
(A1 Refereed original research article in a scientific journal)
(1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
Structural and functional consequences of substitutions at the tyrosine 55 lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase (1997) Fabrichniy IP, Kasho VN, Hyytia T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA
(A1 Refereed original research article in a scientific journal)
The three metal ion mechanism of inorganic pyrophosphatases (1997)
- Protein Engineering
Heikinheimo P, Tuominen V, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase - Functional conservation of the active site of soluble inorganic pyrophosphatases (1996)
- European Journal of Biochemistry
Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, Lahti R
(A1 Refereed original research article in a scientific journal)
The structural basis for pyrophosphatase catalysis (1996)
- Structure
Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases (1995)
- Acta Crystallographica Section D: Biological Crystallography
HEIKINHEIMO P, SALMINEN T, LAHTI R, COOPERMAN B, GOLDMAN A
(A1 Refereed original research article in a scientific journal)
Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.
(A1 Refereed original research article in a scientific journal)