Tero Aittokallio
PhD
teanai@utu.fi Tykistökatu 6 A Turku |
Tero Aittokallio received his PhD in Applied Mathematics from the University of Turku in 2001, under the supervision of Prof. Mats Gyllenberg. He then did his post-doctoral training in the Systems Biology Lab at the Institut Pasteur (2006-2007), with Dr. Benno Schwikowski, where he focused on network biology applications using high-throughput experimental assays and network analysis tools such as Cytoscape. In 2007, Dr. Aittokallio launched his independent career as a principal investigator in the Turku Biomathematics Research Group, where he received a five-year appointment as an Academy of Finland Research Fellow (2007-2012). Tero Aittokallio joined Institute for Molecular Medicine Finland (FIMM) as EMBL Group Leader in the fall of 2011, and was selected as Professor of Statistics and Applied Mathematics at University of Turku in 2015.
Aittokallio's research group focuses on developing and applying integrated computational-experimental approaches to tackle biomedical questions, such as how genes function as interaction networks to carry out and regulate cellular processes, how alterations in these networks contribute to complex traits, such as human diseases, and where and how in the disease network one should target to optimally inhibit the disease phenotypes, such as tumor growth.
Computational statistics.
Scientific computing.
- Identification of Personalized Therapeutic Strategies and Associated Biomarkers in Adult Acute Myeloid Leukemia Using a Functional Drug Sensitivity and Resistance Testing Platform (2012)
- European Journal of Cancer
- Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo (2012)
- Clinical Cancer Research
- Mining high-throughput screens for cancer drug targets - lessons from yeast chemical-genomic profiling and synthetic lethality (2012)
- Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery
- Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection (2012)
- Journal of Biological Chemistry
- Optimized detection of transcription factor binding sites in ChIP-seq experiments (2012)
- Nucleic Acids Research
- Optimizing Detection of Transcription Factor-Binding Sites in ChIP-seq Experiments (2012)
- Nucleic Acids Research
- Pravastatin-induced improvement in coronary reactivity and circulating ATP and ADP levels in young adults with type 1 diabetes (2012)
- Frontiers in Physiology
- Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significance (2012)
- Cancer Research
- The rocky road to personalized medicine: computational and statistical challenges (2012)
- Personalized Medicine
- Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations (2012)
- Algorithms for Molecular Biology
- Fast and Parallelized Greedy Forward Selection of Genetic Variants in Genome-Wide Association Studies (2011) IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS 2011) Okser S, Pahikkala T, Airola A, Aittokallio T, Salakoski T
- PolyAlign –A versatile LC-MS data alignment tool for landmark-selected and automated use (2011)
- International Journal of Proteomics
- Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays (2011)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
- Quantitative Maps of Genetic Interactions in Yeast - Comparative Evaluation and Integrative Analysis (2011)
- BMC Systems Biology
- Quantitative Subcellular Proteome and Secretome Profiling of Influenza A Virus-Infected Human Primary Macrophages (2011)
- PLoS Pathogens
- An update on clinical proteomics in Alzheimer's research (2010)
- Journal of Neurochemistry
- Dealing with missing values in large-scale studies: microarray data imputation and beyond (2010)
- Briefings in Bioinformatics
- Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling (2010)
- Journal of Autoimmunity
- Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study (2010)
- PLoS Genetics
- Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming (2010)
- Immunity