Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo



: Laajala TD, Corander J, Saarinen NM, Makela K, Savolainen S, Suominen MI, Alhoniemi E, Makela S, Poutanen M, Aittokallio T

Publisher: AMER ASSOC CANCER RESEARCH

: 2012

: Clinical Cancer Research

: CLINICAL CANCER RESEARCH

: CLIN CANCER RES

: 16

: 18

: 16

: 4385

: 4396

: 12

: 1078-0432

DOI: https://doi.org/10.1158/1078-0432.CCR-11-3215


Conclusions: In general, the modeling framework enables identification of such biologically significant differences in tumor growth profiles that would have gone undetected or had required considerably higher number of animals when using traditional statistical methods. Clin Cancer Res; 18(16); 4385-96. (C) 2012 AACR.



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