Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays



: Lahti L, Elo LL, Aittokallio T, Kaski S

Publisher: IEEE COMPUTER SOC

: 2011

: IEEE/ACM Transactions on Computational Biology and Bioinformatics

: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS

: IEEE ACM T COMPUT BI

: 1

: 8

: 1

: 217

: 225

: 9

: 1545-5963

DOI: https://doi.org/10.1109/TCBB.2009.38


Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design.



Last updated on 2024-26-11 at 22:24