Semi Helin - UTU Research Portal - UTU Research Portal

Semi Helin

- Senior Researcher,
Turku PET Centre (Independent units)

semhel@utu.fi

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Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder (2025)
- European Journal of Nuclear Medicine and Molecular Imaging
Noppari, Tuomo; Tuisku, Jouni; Lukkarinen, Lasse; Tani, Pekka; Lindberg, Nina; Saure, Emma; Lauerma, Hannu; Tiihonen, Jari; Hirvonen, Jussi; Helin, Semi; Rajander, Johan; Salmi, Juha; Nummenmaa, Lauri
Anorexia nervosa is associated with higher brain mu-opioid receptor availability (2025)
- Molecular Psychiatry
Pak, Kyoungjune; Tuisku, Jouni; Karlsson, Henry K.; Hirvonen, Jussi; Rebelos, Eleni; Pekkarinen, Laura; Sun, Lihua; Latva-Rasku, Aino; Helin, Semi; Rajander, Johan; Karukivi, Max; Nuutila, Pirjo; Nummenmaa, Lauri
APOE4 carriership status influences [11C]PiB white matter retention in cognitively healthy older adults (2025)
- Neurobiology of Disease
Tato-Fernández Claudia; Ekblad Laura L.; Bucci Marco; Tuisku Jouni; Parkkola Riitta; Helin Semi; Rinne Juha O.; Snellman Anniina
Cannabidiol modulates brain molecular alterations, gut microbiota dysbiosis and alcohol self-administration in a mouse model of fetal alcohol spectrum disorder (2025)
- Biomedicine and Pharmacotherapy
Navarrete F.; Cabrera-Rubio R.; Gasparyan A.; Aarnio R.; López-Picón F.; Helin S.; Rajander J.; Collado M.C.; Manzanares J.
Lapsuusiän epilepsia saattaa altistaa myöhäisiän muistisairaudelle = Progression of amyloid accumulation in late adulthood among people with childhood-onset epilepsy (2025)
- Duodecim
Joutsa, Juho; Rinne, Juha O.; Niemi, Kalle J.; Karrasch, Mira; Parkkola, Riitta K.; Saunavaara, Jani; Helin, Semi; Hermann, Bruce B.; Sillanpää, Matti
Neuroinflammation in Parkinson’s disease : A study with [11C]PBR28 PET and cerebrospinal fluid markers (2025)
- Parkinsonism and Related Disorders
Al-Abdulrasul, H.; Ajalin, R.; Tuisku, J.; Zetterberg, H.; Blennow, K.; Vahlberg, T.; Ekblad, L.; Helin, S.; Forsback, S.; Rinne, J.O.; Brück, A.
Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI—Exercise training reverses increased brain activity (2025)
- Diabetes, Obesity and Metabolism
Hentilä, Jaakko; Tuisku, Jouni; Ojala, Ronja; Sun, Lihua; Lietzén, Martin S.; Virtanen, Heidi; Lautamäki, Riikka; Koskensalo, Kalle; Nummenmaa, Lauri; Löyttyniemi, Eliisa; Helin, Semi; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Lahti, Leo; Malm, Tarja; Rinne, Juha O.; Hannukainen, Jarna C.
Progression of Amyloid Accumulation in Late Adulthood Among People With Childhood-Onset Epilepsy (2025)
- Neurology
Joutsa, Juho; Rinne, Juha O.; Niemi, Kalle J.; Karrasch, Mira; Parkkola, Riitta K.; Saunavaara, Jani; Helin, Semi P.; Hermann, Bruce P.; Sillanpää, Matti
Striatal cue-reactivity and neurotransmitter function in gambling disorder (2025)
- Journal of behavioral addictions
Bellmunt-Gil, Albert; Majuri, Joonas; Nummenmaa, Lauri; Helin, Semi; Forsback, Sarita; Rajander, Johan; Kaasinen, Valtteri; Joutsa, Juho
Aberrant type 2 dopamine receptor availability in violent offenders with psychopathy (2024)
- NeuroImage
Lukkarinen, Lasse; Tuisku, Jouni; Sun, Lihua; Helin, Semi; Karlsson, Henry K.; Venetjoki, Niina; Salomaa, Marja; Rautio, Päivi; Hirvonen, Jussi; Lauerma, Hannu; Tiihonen, Jari; Nummenmaa, Lauri
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly (2024)
- Alzheimer's Research and Therapy
Koivumäki Mikko, Ekblad Laura, Lantero-Rodriguez Juan, Ashton Nicholas J., Karikari Thomas K., Helin Semi, Parkkola Riitta, Lötjönen Jyrki, Zetterberg Henrik, Blennow Kaj, Rinne Juha O., Snellman Anniina
Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET (2024)
- Neurobiology of Disease
Tato-Fernández Claudia, Ekblad Laura L., Pietilä Elina, Saunavaara Virva, Helin Semi, Parkkola Riitta, Zetterberg Henrik, Blennow Kaj, Rinne Juha O., Snellman Anniina
In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature (2024)
- EJNMMI Radiopharmacy and Chemistry
Helin Semi, Rajander Johan, Aromaa Jussi, Arponen Eveliina, Helin Jatta S, Solin Olof
Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation : A 5-year follow-up [11C]PIB-PET study (2024)
- Neurobiology of Disease
Pietilä Elina, Snellman Anniina, Tuisku Jouni, Helin Semi, Viitanen Matti, Jula Antti, Rinne Juha O., Ekblad Laura L.
P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study (2024)
- EJNMMI Research
Lehto, Jussi; Aarnio, Richard; Tuisku, Jouni; Sucksdorff, Marcus; Koivumäki, Esa Mikko; Nylund, Marjo; Helin, Semi; Rajander, Johan; Danon, Jonathan; Gilchrist, Jayson; Kassiou, Michael; Oikonen, Vesa; Airas, Laura
[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue (2023)
- European Journal of Nuclear Medicine and Molecular Imaging
Sun Lihua, Aarnio Richard, Herre Erika Atencio, Kärnä Salli, Palani Senthil, Virtanen Helena, Liljenbäck Heidi, Virta Jenni, Honkaniemi Aake, Oikonen Vesa, Han Chunlei, Laurila Sanna, Bucci Marco, Helin Semi, Yatkin Emrah, Nummenmaa Lauri, Nuutila Pirjo, Tang Jing, Roivainen Anne
Adenosine A2A receptor availability in patients with early- and moderate-stage Parkinson’s disease (2023)
- Journal of Neurology
Waggan Imran, Rissanen Eero, Tuisku Jouni, Joutsa Juho, Helin Semi, Parkkola Riitta, Rinne Juha O, Airas Laura
APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly (2023)
- Alzheimer's Research and Therapy
Snellman Anniina, Ekblad Laura L., Tuisku Jouni, Koivumäki Mikko, Ashton Nicholas J., Lantero-Rodriguez Juan, Karikari Thomas K., Helin Semi, Bucci Marco, Löyttyniemi Eliisa, Parkkola Riitta, Karrasch Mira, Schöll Michael, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.
Endogenous Opioid Release After Orgasm in Man: A Combined PET/Functional MRI Study (2023)
- Journal of Nuclear Medicine
Jern Patrick, Chen Jinglu, Tuisku Jouni, Saanijoki Tiina, Hirvonen Jussi, Lukkarinen Lasse, Manninen Sandra, Helin Semi, Putkinen Vesa, Nummenmaa Lauri
Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease (2023)
- Neurobiology of Disease
Snellman Anniina, Ekblad Laura L., Ashton Nicholas J., Karikari Thomas K., Lantero-Rodriguez Juan, Pietilä Elina, Koivumäki Mikko, Helin Semi, Karrasch Mira, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.