Jorma Määttä
PhD., Adjunct Professor
Turun tautimallinnuskeskus TCDM jmaatta@utu.fi +358 29 450 4466 +358 50 400 4219 Kiinamyllynkatu 10 Turku : C411 |
myeloid cells; chronic inflammation; sex steroid receptor; bone biology; tumor macrophage; bioimaging
ADMIO -consortium and IPP / drug research and development. TCDM
Education and degrees completed
Doctor of Philosophy 17.8.1998, University of Turku, Medical Faculty
Master of Science 11.3.1993, University of Turku, Biotechnology
High school graduation 31.5.1987, Rauhala High School, Lieksa
Military service 13.6 1988 – 8.5.1989, SissiK/P-KR
Title of Docent 27.3.2006 Docent (Adjunct Professor) of Molecular Cell Biology, Institute of Biochemistry, University of Turku.
Other education
21.6.2018 Official teacher’s qualification (decree 794/2004; 60 credits ECTS B), University of Turku, Faculty of Education Radiation safety principal, 2007, University of Helsinki
Current position University Lecturer, Principal Investigator, University of Turku, Institute of Biomedicine 1.1.2018 -
Previous work experience
1.1.2016 – 31.12.2017 University Research Fellow at the University of Turku, Institute of Biomedicine
1.9.2011 – 31.12.2015 University Research Fellow at the University of Turku, Department of Cell Biology and Anatomy (50%) and the University of Eastern Finland, School of Pharmaceutics (50%)
1.9. 2007 – 31.8.2011 Senior Scientist, Bone Analysis Unit Manager of Turku Center for Disease Modeling
1.1.2006 – 31.8.2007 Senior Scientist, Professor Kalervo Väänänen’s research group, Department of Anatomy, University of Turku
1.9.2005 – 31.12.2005 Senior Scientist, Professor Pirkko Härkönen’s research group, Department of Anatomy, University of Turku
1.1.2004 – 31.8.2005 Senior Scientist, Docent Markku Salmivirta’s research group Turku Centre of Biotechnology
1.8.2003 – 31.12.2003 Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.8.2002 – 31.7.2003 Postdoctoral Researcher of the Foundation of the Finnish Cancer Institute
1.8.1999 – 31.7.2002 Postdoctoral Researcher of the Academy of Finland
1.1.1999 – 31.12.2004 Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.7.1998 – 31.12.1998 Research Fellow in Docent Ari Hinkkanen’s research group Department of Biochemistry and Pharmacy, Åbo Akademi University
1.2.1995 – 30.6.1998 Turku Post Graduate School of Biomed. Sciences, post graduate student
1.1.1993 – 31.1.1995 Research assistant, Department of Virology, University of Turku
1991, 1992, 1.6-31.8. Research assistant, Department of Virology, University of Turku
4.6.1990 – 31.8.1990 Research assistant, Huhtamäki Oy Leiras Ltd. Biotechnological Research Laboratory
In my research, the function of myeloid cells and mesenchymal cells in the process of calvarial implant integration (ADMIO-consortium). Further, we study also the role of sex steroid receptors on regulation of myeloid cells. This includes the role of myeloid cells in chronic inflammations (e.g. chronic colitis) as well as in tumors.
Teaching responsibilities include lecturing and contact teaching on the fields of (molecular) cell biology and histology for medical, biomedical and dentistry students
- SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells (2018)
- Inflammation
- Tuumorimakrofaagit luumetastaasien muodostumisessa (2018)
- BestPractice Onkologia ja hematologia
- Fam3c modulates osteogenic differentiation by down-regulating Runx2 (2017)
- Differentiation
- Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI (2017)
- Journal of Pharmacology and Experimental Therapeutics
- Teriparatide Treatment in Patients With WNT1 or PLS3 Mutation-Related Early-Onset Osteoporosis: A Pilot Study (2017)
- Journal of Clinical Endocrinology and Metabolism
- Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations (2016)
- Journal of Immunology
- Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density (2016)
- BoneKEy Reports
- The role of tumour-associated macrophages in bone metastasis (2016)
- Journal of Bone Oncology
- Tsoledronaatti toimii tehokkaasti rintasyöpäsoluissa liposomaalisena tai kalsiumiin sitoutuneena (2016)
- BestPractice Onkologia ja hematologia
- Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells (2016)
- European Journal of Pharmaceutical Sciences
- Human breast cancer cells educate macrophages toward the M2 activation status. (2015)
- Breast Cancer Research
- Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells. (2015)
- BMC Cancer
- Macrophages and pathophysiology of bone cancers (2015) Bone Cencer: Primary Bone Cancer and Bone Metastasis, 2nd Ed. Sofia Sousa, Jorma A. Määttä
- Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. – Noradrenergic neurone NPY and obesity (2015)
- Acta Physiologica
- Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype. (2015)
- Transgenic Research
- Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells (2015)
- Cancer Letters
- Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells. (2014)
- Molecular Cancer
- Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. (2013)
- Journal of Experimental Medicine
- Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice (2013)
- FASEB Journal
- Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
- BoneKEy Reports