Heidi Korhonen
University teacher
hejoli@utu.fi +358 29 450 3181 +358 46 920 5524 Office: K217 ORCID identifier: https://orcid.org/0000-0001-6974-9907 |
Oligonucleotide synthesis; organic synthesis; mechanistic studies of RNA phosphodiester bond; DNA templated ligation; DNA nanostructures
University of Turku, Department of Chemistry, university teacher (2018-)
University of Turku, Department of Chemistry, university lecturer (2014-2018)
University of Durham, UK, post doctoral fellow (2013-2014)
University of Turku, Department of Chemistry, university teacher (2011-2013)
University of Turku, Department of Chemistry, PhD in organic chemistry, 2011
My research interests are:
Mechanistic studies of RNA phosphodiester bond and other biologically active phosphate esters.
Nucleoside phosphorylation.
Enzyme-free, DNA-templated ligation reactions.
DNA nanostructures.
I´m one of the teachers in courses:
KEMI6135 Experimental Methods for Chemists
KEMI6111 Laboratory Experiments for Chemists I, Intermediate Level
KEMI6307 Chemistry, Laboratory Experiments, Intermediate Level
- The Cleavage of RNA Model Compounds: The Interplay Between the Nucleophile and the Leaving Group (2024)
- Journal of Physical Organic Chemistry
(A1 Refereed original research article in a scientific journal) - The role of the maleimide ring system on the structure-activity relationship of showdomycin (2022)
- European Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core (2021)
- Bioconjugate Chemistry
(A1 Refereed original research article in a scientific journal) - Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates (2021)
- Molecules
(A1 Refereed original research article in a scientific journal) - Identification of Tree Species by Their Defense Compounds: A Study with Leaf Buds of White and Silver Birches (2021)
- Journal of Chemical Education
(A1 Refereed original research article in a scientific journal) - Kinetic and NMR spectroscopic study of the Chemical Stability and Reaction Pathways of Sugar Nucleotides (2021)
- Nucleosides, Nucleotides and Nucleic Acids
(A1 Refereed original research article in a scientific journal) - Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker (2020)
- Organic Letters
(A1 Refereed original research article in a scientific journal) - Immobilized Carbohydrates for Preparation of 3'-Glycoconjugated Oligonucleotides (2020)
- Current Protocols in Nucleic Acid Chemistry
(A1 Refereed original research article in a scientific journal) - DNA-Templated N(Me)-Alkoxyamine Glycosylation (2018)
- Organic Letters
(A1 Refereed original research article in a scientific journal) - A procedure for the preparation and isolation of nucleoside-5 '-diphosphates (2015)
- Beilstein Journal of Organic Chemistry
(A1 Refereed original research article in a scientific journal) - Metal ion‑promoted cleavage of nucleoside diphosphosugars: a model for reactions of phosphodiester bonds in carbohydrates (2015)
- Journal of Biological Inorganic Chemistry
(A1 Refereed original research article in a scientific journal) - PPN pyrophosphate: A New Reagent for the Preparation of Nucleoside Triphosphates (2015)
- Phosphorus, Sulfur, and Silicon and the Related Elements
(A1 Refereed original research article in a scientific journal) - The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein (2015)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Phosphate analogues in the dissection of mechanism (2014)
- Current Opinion in Chemical Biology
(A2 Refereed review article in a scientific journal ) - ss(LG) values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification (2013)
- Journal of Physical Organic Chemistry
(A2 Refereed review article in a scientific journal ) - There is no universal mechanism for the cleavage of RNA model compounds in the presence of metal ion catalysts (2013)
- Organic and Biomolecular Chemistry
(A1 Refereed original research article in a scientific journal) - The Mechanism of Cleavage and Isomerisation of RNA Promoted by an Efficient Dinuclear Zn2+ Complex (2012)
- Chemistry - A European Journal
(A1 Refereed original research article in a scientific journal)