Juha Mykkänen
Dosentti (Adjunct professor)
juha.mykkanen@utu.fi +358 29 450 4364 +358 50 406 3612 Kiinamyllynkatu 10 Turku Office: B503 ORCID identifier: https://orcid.org/0000-0001-9898-2660(external) The Cardiovascular Risk in Young Finns Study (YFS)(external) |
Areas of expertise
cardiovascular and metabolic risk factors; metabolic disease; obesity; insulin resistance and type 2 diabetes; molecular genetics and genomics; metabolomics; transcriptomics; omics data analysis; statistics; type 1 diabetes; lysinuric protein intolerance; research project planning
cardiovascular and metabolic risk factors; metabolic disease; obesity; insulin resistance and type 2 diabetes; molecular genetics and genomics; metabolomics; transcriptomics; omics data analysis; statistics; type 1 diabetes; lysinuric protein intolerance; research project planning
Biography
EDUCATION AND DEGREES
2015 Adjunct professor (docent) of Molecular genetics, University of Turku (UTU)
2003 PhD, Medical genetics, UTU
1998 MSc, Genetics, UTU
CURRENT POSITION
Senior scientist, Research Centre of Applied and Preventive Cardiovascular Medicine, Medical Faculty, UTU
PAST POSITIONS
2009 – 2015 Senior scientist, Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study, Department of Paediatrics and Adolescent Medicine, Turku University Hospital (TUH)
2005 – 2008 Academy of Finland Post-doctoral Researcher, Turku Centre for Biotechnology, UTU
2003 – 2008 Post-doctoral researcher, Turku Centre for Biotechnology, UTU
1998 – 2003 Post-graduate (PhD) training, Department of Medical Genetics, UTU
2000 – 2002 Part-time teacher, Department of Biology, UTU
1998 – 1999 Assistant (8 months), Department of Medical Genetics, UTU
1995 – 1997 Part-time research assistant, Department of Medical Genetics, UTU
EDUCATION AND DEGREES
2015 Adjunct professor (docent) of Molecular genetics, University of Turku (UTU)
2003 PhD, Medical genetics, UTU
1998 MSc, Genetics, UTU
CURRENT POSITION
Senior scientist, Research Centre of Applied and Preventive Cardiovascular Medicine, Medical Faculty, UTU
PAST POSITIONS
2009 – 2015 Senior scientist, Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study, Department of Paediatrics and Adolescent Medicine, Turku University Hospital (TUH)
2005 – 2008 Academy of Finland Post-doctoral Researcher, Turku Centre for Biotechnology, UTU
2003 – 2008 Post-doctoral researcher, Turku Centre for Biotechnology, UTU
1998 – 2003 Post-graduate (PhD) training, Department of Medical Genetics, UTU
2000 – 2002 Part-time teacher, Department of Biology, UTU
1998 – 1999 Assistant (8 months), Department of Medical Genetics, UTU
1995 – 1997 Part-time research assistant, Department of Medical Genetics, UTU
Research
I have dedicated my whole career on human health related research. This started already during my pre-graduate stage when I was working in Adjunct professor Jaana Lähdetie's research group at the Department of Medical Genetics (UTU) studying sperm aneuploidy of testicular cancer patients treated with radiotherapy. After my M.Sc., I familiarized with molecular genetics of hereditary diseases in children. In my doctoral dissertation I studied the molecular genetics of hereditary lysinuric protein intolerance (LPI) disease under the guidance Prof. emeritus of Pertti Aula at the Medical Genetics department. During this time I familiarized with various methods of human genomics and the so-called Finnish disease heritage.
During my post-doc studies, I moved to the Turku Centre for Biotechnology (UTU) to study the development of Type 1 diabetes as part of the Finnish DIPP study. During this time, I studied of Type 1 diabetes, molecular immunology and various genomic biomedical research methods such genome-wide microarrays. During the post-doc period I was a post-doctoral researcher of the Academy of Finland, the subject of the Molecular Markers of Type 1 diabetes, where biospecimens collected from DIPP children were analysed using various microarray platforms (in-house cDNA, Affymetrix and Illumina) in order to find genes or gene networks that change early in the course of Type 1 diabetes development.
The third phase of my research career began in 2009 as a senior researcher at the DIPP Research Clinic (Department of Paediatrics and Adolescent Medicine, TUH) led by Prof. emeritus Olli Simell. My research interest was to dissect and identify factors that modulate the risk for Type 1 diabetes related autoimmunity.
The fourth phase of my research career started in March 2015 as a senior researcher in The Cardiovascular Risk in Young Finns Study (YFS) coordinated by Academy Professor Olli Raitakari at the Research Centre of Applied and Preventive Cardiovascular Medicine (UTU), where risk factors for cardiovascular and metabolic diseases are studied in great detail. The main aim of my current research is to dissect the complex interplay of human genome, transcriptome and metabolome with risk factors of cardiovascular and metabolic diseases, both in cross-sectional and longitudinal settings, to increase our understanding of pathophysiology of cardiovascular and metabolic diseases.
I have dedicated my whole career on human health related research. This started already during my pre-graduate stage when I was working in Adjunct professor Jaana Lähdetie's research group at the Department of Medical Genetics (UTU) studying sperm aneuploidy of testicular cancer patients treated with radiotherapy. After my M.Sc., I familiarized with molecular genetics of hereditary diseases in children. In my doctoral dissertation I studied the molecular genetics of hereditary lysinuric protein intolerance (LPI) disease under the guidance Prof. emeritus of Pertti Aula at the Medical Genetics department. During this time I familiarized with various methods of human genomics and the so-called Finnish disease heritage.
During my post-doc studies, I moved to the Turku Centre for Biotechnology (UTU) to study the development of Type 1 diabetes as part of the Finnish DIPP study. During this time, I studied of Type 1 diabetes, molecular immunology and various genomic biomedical research methods such genome-wide microarrays. During the post-doc period I was a post-doctoral researcher of the Academy of Finland, the subject of the Molecular Markers of Type 1 diabetes, where biospecimens collected from DIPP children were analysed using various microarray platforms (in-house cDNA, Affymetrix and Illumina) in order to find genes or gene networks that change early in the course of Type 1 diabetes development.
The third phase of my research career began in 2009 as a senior researcher at the DIPP Research Clinic (Department of Paediatrics and Adolescent Medicine, TUH) led by Prof. emeritus Olli Simell. My research interest was to dissect and identify factors that modulate the risk for Type 1 diabetes related autoimmunity.
The fourth phase of my research career started in March 2015 as a senior researcher in The Cardiovascular Risk in Young Finns Study (YFS) coordinated by Academy Professor Olli Raitakari at the Research Centre of Applied and Preventive Cardiovascular Medicine (UTU), where risk factors for cardiovascular and metabolic diseases are studied in great detail. The main aim of my current research is to dissect the complex interplay of human genome, transcriptome and metabolome with risk factors of cardiovascular and metabolic diseases, both in cross-sectional and longitudinal settings, to increase our understanding of pathophysiology of cardiovascular and metabolic diseases.
Teaching
Currently I supervise advanced studies or thesis in (bio)medicine.
Publications
- Early Infant Diet and Islet Autoimmunity in the TEDDY Study (2018)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes (2018)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity (2018)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Serum 25-hydroxyvitamin D concentration at birth in children screened for HLA-DQB1 conferred genetic risk for type 1 diabetes (2018)
- Diabetologia
(Other publication) - Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study (2017)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance (2017)
- JIMD Reports
(A1 Refereed original research article in a scientific journal) - Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study (2017)
- Acta Diabetologica
(A1 Refereed original research article in a scientific journal) - Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls (2017)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study (2017)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study (2017)
- Developmental Psychobiology
(A1 Refereed original research article in a scientific journal) - Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study (2016)
- Emerging Infectious Diseases
(Other publication) - Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort (2016)
- Clinical Gastroenterology and Hepatology
(A1 Refereed original research article in a scientific journal) - Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study (2016)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort (2016)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI) (2016)
- Metabolism
(A1 Refereed original research article in a scientific journal) - Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing (2016)
- Journal of Diabetes Research
(A1 Refereed original research article in a scientific journal) - Reduced β-cell function in early preclinical type 1 diabetes (2016)
- European Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes (2016)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - The role of innate immunity in Type 1 Diabetes (T1D) (2016)
- Scandinavian Journal of Immunology
(Other publication)