A1 Refereed original research article in a scientific journal

Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort



Authors: Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG, Lernmarklo A, Simell O, Toppari J, Krischer JP, Akolkar B, Rich SS, Agardh D, She JX; Teddy Study group

Publisher: PUBLIC LIBRARY SCIENCE

Publication year: 2016

Journal: PLoS ONE

Journal name in source: PLOS ONE

Journal acronym: PLOS ONE

Article number: ARTN e0152476

Volume: 11

Issue: 3

Number of pages: 20

ISSN: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0152476(external)


Abstract

In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden.



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Last updated on 2024-26-11 at 19:40