Gennadi Egutkin
PhD, Docent
genyeg@utu.fi +358 29 450 4388 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-6684-7982 |
My research focus for the past 25 years has been to investigate cellular metabolism in various pathophysiological states. I have especially contributed to the papers dealing with role of purine-converting enzymes in cancer, inflammation and vascular remodelling. Overall, I have >100 publications including six Invited Review Articles and four Book Chapters.
Principal supervisor (PS) or co-supervisor (co-S) for for the following theses: Bachelor’s thesis of Camilla Tallgren (Turku University of Applied Sciences; May 2011, PS) • Master of Science (MSc) thesis of Mikko Helenius (UTU; March 2011, PS) • PhD thesis of Mariachiara Zuccarini (University of Chieti-Pescara, Italy; April 2015, PS) • PhD thesis of Mikko Helenius (University of Helsinki; October 2015, co-S) • MSc thesis of Marius Paul (University of Bonn [UB], Germany; May 2019, PS) • MSc thesis of Nora Kreisig (UB, September 2024, PS) • MSc thesis of Samuel Svärd (UTU; November 2024, PS) • PhD thesis of Karolina Losenkova (UTU; March 2025, PS) • MSc thesis of Julia Baier (UB, April 2026, PS). Currently, I am supervising PhD Theses of Samuel Svärd (UTU, PS), and Shaghayegh Hasanpour (UTU, co-S), and MSc theses of Ursula von Danwitz (UB, PS).
The following visiting researchers, undergraduate and PhD students received training in MediCity under my supervision: Dr. Nathalie Mercier (Nancy, France; 2008–2010) • Anne Meyer (UB, April–June 2014) • Justyna Kowal (University of Copenhagen, Denmark, December 2014) • Mariachiara Zuccarini (University of Chieti-Pescara, Italy, September 2014 – February 2015) • Valeria Quarona (University of Torino, Italy, April 2015) • Octavia Cadassou (University of Lyon, France, January – February 2017) • Karolina Losenkova (Moscow Institute of Physics, Russia, October 2015 – November 2017) • Julian Zeiner (UB, May – October 2017) • Marius Paul (UB, January – May 2018) • Corinna Weiler (UB, May – October 2021) • Nora Kreisig (UB, May – October 2023) • Joanna Pomeroy (University of Portsmouth, UK, July 2024) • Ursula Johanna von Danwitz (UB, May – October 2025) • Julia Baier (UB, July 2025 – February 2026).
- Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate (2015)
- PLoS ONEFASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Toll like receptor-9 and CD73 may act on the same pathway to induce immunosuppression in triple negative breast cancer cells (2015)
- Cancer Research
(O2 Muu julkaisu ) - Adenosine activates brown adipose tissue and recruits beige adipocytes via A(2A) receptors (2014)
- Nature
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms. (2014)
- Molecular Cancer Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs (2014)
- Mediators of Inflammation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis (2014)
- Critical Care Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Enzymes involved in metabolism of extracellular nucleotides and nucleosides – Functional implications and measurement of activities (2014)
- Critical Reviews in Biochemistry and Molecular Biology
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Markers of purinergic signaling give new insight on vascular inflammation, thrombosis, tobacco smoke and peripheral artery disease (2014)
- Purinergic Signalling
(O2 Muu julkaisu ) - Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice (2014)
- Pediatric Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study (2014)
- The Lancet Respiratory Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain (2013)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Enzyme-coupled assays for simultaneous detection of nanomolar ATP, ADP, AMP, adenosine, inosine and pyrophosphate concentrations in extracellular fluids (2012)
- BBA - Molecular Cell Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities (2012)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier (2008)
- European Journal of Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Mechanism of action of IFN-beta in the treatment of multiple sclerosis - A special reference to CD73 and adenosine (2007)
- Annals of the New York Academy of Sciences
(A4 Vertaisarvioitu artikkeli konferenssijulkaisussa) - Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo (2006)
- Arthritis and Rheumatism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by Ecto-5'-nucleotidase/CD73-dependent mechanism. (2003)
- Journal of Biological Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. (2002)
- Biochemical Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Extracellular ATP formation on vascular endothelial cells is mediated by ecto-nucleotide kinase activities via phosphotransfer reactions. (2001)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
