Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku |
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
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- MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
- Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
- BBA - Biochimica et Biophysica Acta
- Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
- Journal of Biological Chemistry
- Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism (2012)
- PLoS ONE
- Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism (2012)
- PLoS ONE
- Structure-activity relationship of sphingomyelin analogs with sphingomyelinase from Bacillus cereus (2012)
- BBA - Biomembranes
- Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors (2011)
- MedChemComm
- Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors (2011)
- MedChemComm
- Comparison of Virtual High-Throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors (2011)
- Journal of Chemical Information and Modeling
- Comparison of Virtual High-Throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors (2011)
- Journal of Chemical Information and Modeling
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