Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku |
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
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- Exploring kainate receptor pharmacology using molecular dynamics simulations (2010)
- Neuropharmacology
- Exploring kainate receptor pharmacology using molecular dynamics simulations (2010)
- Neuropharmacology
- Ligand-binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors (2010)
- Journal of Biological Chemistry
- Ligand-binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors (2010)
- Journal of Biological Chemistry
- Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion (2010)
- Oncogene
- Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion (2010)
- Oncogene
- Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine (2010)
- Neuropharmacology
- Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine (2010)
- Neuropharmacology
- Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin beta 1, and Contributes to Melanomagenesis (2010)
- Journal of Biological Chemistry
- Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin beta 1, and Contributes to Melanomagenesis (2010)
- Journal of Biological Chemistry
- Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
- Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
- Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
- Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine (2009)
- Journal of Biological Chemistry
- Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine (2009)
- Journal of Biological Chemistry
- Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations (2009)
- PLoS ONE
- Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations (2009)
- PLoS ONE
- Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
- Proteins
- Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
- Proteins
- Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors (2008)
- Journal of Pharmacology and Experimental Therapeutics
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