Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku |
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
4 of 7
- Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
- Journal of Biological Chemistry
- Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism (2012)
- PLoS ONE
- Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism (2012)
- PLoS ONE
- Structure-activity relationship of sphingomyelin analogs with sphingomyelinase from Bacillus cereus (2012)
- BBA - Biomembranes
- Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors (2011)
- MedChemComm
- Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors (2011)
- MedChemComm
- Comparison of Virtual High-Throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors (2011)
- Journal of Chemical Information and Modeling
- Comparison of Virtual High-Throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors (2011)
- Journal of Chemical Information and Modeling
- Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function (2011)
- Journal of the American Chemical Society
- Full and Partial Agonism of Ionotropic Glutamate Receptors Indicated by Molecular Dynamics Simulations (2011)
- Journal of Chemical Information and Modeling
- Full and Partial Agonism of Ionotropic Glutamate Receptors Indicated by Molecular Dynamics Simulations (2011)
- Journal of Chemical Information and Modeling
- Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors (2011)
- Journal of Medicinal Chemistry
- Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors (2011)
- Journal of Medicinal Chemistry
- Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors (2011)
- Journal of Medicinal Chemistry
- A small-molecule inhibitor of integrin alpha 2 beta 1 introduces a new strategy for antithrombotic therapy (2010)
- Thrombosis and Haemostasis
- A small-molecule inhibitor of integrin alpha 2 beta 1 introduces a new strategy for antithrombotic therapy (2010)
- Thrombosis and Haemostasis
- Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A (2010)
- Journal of Biological Chemistry
- Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A (2010)
- Journal of Biological Chemistry
- Efficient Virtual Screening Using Multiple Protein Conformations Described as Negative Images of the Ligand-Binding Site (2010)
- Journal of Chemical Information and Modeling
- Efficient Virtual Screening Using Multiple Protein Conformations Described as Negative Images of the Ligand-Binding Site (2010)
- Journal of Chemical Information and Modeling
UTU Research Portal