Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku |
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
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- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
- Journal of Molecular Graphics and Modelling
- Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
- Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
- Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
- Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
- Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
- Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
- A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
- A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
- A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
- A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
- L-Arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae (2014)
- Applied Microbiology and Biotechnology
- Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
- Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
- Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
- 2NH and 3OH are crucial structural requirements in sphingomyelin for sticholysin II binding and pore formation in bilayer membranes (2013)
- BBA - Biomembranes
- MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
- MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
- MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
- Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
- BBA - Biochimica et Biophysica Acta
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