Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku |
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
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- In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs (2020)
- European Journal of Pharmaceutical Sciences
- In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species (2020)
- Xenobiotica
- Screening of Natural Products Targeting SARS-CoV-2-ACE2 Receptor Interface - A MixMD Based HTVS Pipeline (2020)
- Frontiers in Chemistry
- A Practical Perspective: The Effect of Ligand Conformers on the Negative Image-Based Screening (2019)
- International Journal of Molecular Sciences
- Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes (2019)
- Xenobiotica
- Fragment- and negative image-based screening of phosphodiesterase 10A inhibitors (2019)
- Chemical Biology and Drug Design
- Getting Docking into Shape Using Negative Image-Based Restoring (2019)
- Journal of Chemical Information and Modeling
- Suitability of MMGBSA for the selection of correct ligand binding modes from docking results (2019)
- Chemical Biology and Drug Design
- Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018)
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Discovery of Retinoic Acid-Related Orphan Receptor gamma t Inverse Agonists via Docking and Negative Image-Based Screening (2018)
- ACS Omega
- Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana (2018)
- Scientific Reports
- Improving Docking Performance Using Negative Image-Based (2018)
- Frontiers in Pharmacology
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 (2018)
- Molecular Pharmaceutics
- Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors (2018)
- Frontiers in Chemistry
- Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors (2017)
- Journal of Medicinal Chemistry
- Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing (2017) Seppala J, Bernardi RC, Haataja TJK, Hellman M, Pentikainen OT, Schulten K, Permi P, Ylanne J, Pentikainen U
- Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes (2016)
- Xenobiotica
- The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes (2016)
- Biophysical Journal
- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
- Journal of Molecular Graphics and Modelling
- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
- Journal of Molecular Graphics and Modelling
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