Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-7188-4016 |
Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications 
7 of 7
- Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D - Role of the conserved arginine 507 and glutamate 727 residues (2002)
- European Journal of Biochemistry
(A1 Refereed original research article in a scientific journal) - Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor (2002)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy (2002)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Characterization of bile salt/cyclodextrin interactions using isothermal titration calorimetry (2001)
- Langmuir
(A1 Refereed original research article in a scientific journal) - Selective binding of collagen subtypes by integrin alpha I-1, alpha I-2, and alpha I-10 domains (2001)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Integrin alpha I-2 domain recognizes type I and type IV collagens by different mechanisms (2000)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - A dimeric ternary complex of FGFR1, heparin and FGF-1 leads to an 'electrostatic sandwich' model for heparin binding (1999)
- Structure
(A1 Refereed original research article in a scientific journal) - A dimeric ternary complex of FGFR1, heparin and FGF-1 leads to an 'electrostatic sandwich' model for heparin binding (vol 7, pg 699, 1999) (1999)
- Structure
(A1 Refereed original research article in a scientific journal) - A peptide inhibiting the collagen binding function of integrin alpha I-2 domain (1999)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - "RKKH" peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain (1999)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition (1998)
- EMBO Journal
(A1 Refereed original research article in a scientific journal) - The core domain of retrotransposon integrase in Hordeum: Predicted structure and evolution (1998)
- Molecular Biology and Evolution
(A1 Refereed original research article in a scientific journal)
UTU Research Portal