Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-7188-4016 |
Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications 
5 of 7
- Exploring kainate receptor pharmacology using molecular dynamics simulations (2010)
- Neuropharmacology
(A1 Refereed original research article in a scientific journal) - Exploring kainate receptor pharmacology using molecular dynamics simulations (2010)
- Neuropharmacology
(A1 Refereed original research article in a scientific journal) - Ligand-binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors (2010)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Ligand-binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors (2010)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion (2010)
- Oncogene
(A1 Refereed original research article in a scientific journal) - Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion (2010)
- Oncogene
(A1 Refereed original research article in a scientific journal) - Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine (2010)
- Neuropharmacology
(A1 Refereed original research article in a scientific journal) - Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine (2010)
- Neuropharmacology
(A1 Refereed original research article in a scientific journal) - Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin beta 1, and Contributes to Melanomagenesis (2010)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin beta 1, and Contributes to Melanomagenesis (2010)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine (2009)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine (2009)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations (2009)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations (2009)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
- Proteins
(A1 Refereed original research article in a scientific journal) - Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
- Proteins
(A1 Refereed original research article in a scientific journal) - Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors (2008)
- Journal of Pharmacology and Experimental Therapeutics
(A1 Refereed original research article in a scientific journal)
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