Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-7188-4016 |
Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications 
4 of 14
- Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018)
- Journal of Enzyme Inhibition and Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Discovery of Retinoic Acid-Related Orphan Receptor gamma t Inverse Agonists via Docking and Negative Image-Based Screening (2018)
- ACS Omega
(A1 Refereed original research article in a scientific journal) - Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Improving Docking Performance Using Negative Image-Based (2018)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 (2018)
- Molecular Pharmaceutics
(A1 Refereed original research article in a scientific journal) - Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors (2018)
- Frontiers in Chemistry
(A1 Refereed original research article in a scientific journal) - Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors (2017)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing (2017) Seppala J, Bernardi RC, Haataja TJK, Hellman M, Pentikainen OT, Schulten K, Permi P, Ylanne J, Pentikainen U
(A1 Refereed original research article in a scientific journal) - Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes (2016)
- Xenobiotica
(A1 Refereed original research article in a scientific journal) - The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes (2016)
- Biophysical Journal
(A1 Refereed original research article in a scientific journal)
UTU Research Portal