Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-7188-4016 |
Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications
- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
- Journal of Molecular Graphics and Modelling
(A1 Refereed original research article in a scientific journal) - Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
(A1 Refereed original research article in a scientific journal) - Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
(A1 Refereed original research article in a scientific journal) - Ultrafast protein structure-based virtual screening with Panther (2015)
- Journal of Computer-Aided Molecular Design
(A1 Refereed original research article in a scientific journal) - A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - L-Arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae (2014)
- Applied Microbiology and Biotechnology
(A1 Refereed original research article in a scientific journal) - Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
(A1 Refereed original research article in a scientific journal) - Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
(A1 Refereed original research article in a scientific journal) - Molecular and ecological signs of mitochondrial adaptation: consequences for introgression? (2014)
- Heredity
(A1 Refereed original research article in a scientific journal) - 2NH and 3OH are crucial structural requirements in sphingomyelin for sticholysin II binding and pore formation in bilayer membranes (2013)
- BBA - Biomembranes
(A1 Refereed original research article in a scientific journal) - MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
(A1 Refereed original research article in a scientific journal) - MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
(A1 Refereed original research article in a scientific journal) - MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions (2013)
- Journal of Chemical Information and Modeling
(A1 Refereed original research article in a scientific journal) - Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
- BBA - Biochimica et Biophysica Acta
(A1 Refereed original research article in a scientific journal)