Georgy Belogurov
PhD
gebelo@utu.fi +358 29 450 4775 +358 50 475 7149 Tykistökatu 6 Turku : 6057 |
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Ph.D. - University of Turku, Dept. of Biochemistry, Finland, 2005
Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009
Principal investigator - University of Turku, Dept. of Biochemistry, Finland, 2009-2020
Principal investigator - University of Turku, Dept. of Life Technologies, Finland, 2020-
Associate Professor - University of Turku, Dept. of Life Technologies, Finland, 2023-
The properties of a cell are determined by the information encoded in its genome. Understanding how such information is differentially and dynamically retrieved in response to environmental changes and cellular needs is a major challenge facing molecular biology. The focal point of our research is a multisubunit RNA polymerase, the enzyme that carries out the first step in gene expression, synthesis of RNA. We study several classes of RNA polymerases with the aim of understanding the fundamental aspects of transcription regulation, catalytic mechanism, and developing medically relevant transcription inhibitors.
Molecular Biology, Bioproduction, Bioinformatics, Enzyme kinetics
- RNA polymerase gate loop guides the nontemplate DNA strand in transcription complexes (2016)
- Proceedings of the National Academy of Sciences of the United States of America
- Creative Math of RNA Polymerase III Termination: Sense Plus Antisense Makes More Sense (2015)
- Molecular Cell
- Monitoring translocation of multisubunit RNA polymerase along the DNA with fluorescent base analogues (2015) Bacterial Transcriptional Control Malinen Anssi M., Turtola Matti, Belogurov Georgiy A.
- Regulation of Transcript Elongation (2015)
- Annual Review of Microbiology
- CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase (2014)
- Nature Communications
- Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
- Active site opening and closure control translocation of multisubunit RNA polymerase (2012)
- Nucleic Acids Research
- Na+-translocating Membrane Pyrophosphatases Are Widespread in the Microbial World and Evolutionarily Precede H+-translocating Pyrophosphatases (2011)
- Journal of Biological Chemistry
- The beta Subunit Gate Loop Is Required for RNA Polymerase Modification by RfaH and NusG (2011)
- Molecular Cell
- Functional regions of the N-terminal domain of the antiterminator RfaH (2010)
- Molecular Microbiology
- Functional specialization of transcription elongation factors (2009)
- EMBO Journal
- Transcription inactivation through local refolding of the RNA polymerase structure (2009)
- Nature
- A CBS domain-containing pyrophosphatase of Moorella thermoacetica is regulated by adenine nucleotides. (2007)
- Biochemical Journal
- Allosteric control of the RNA polymerase by the elongation factor RfaH (2007)
- Nucleic Acids Research
- Na+-pyrophosphatase: A novel primary sodium pump (2007)
- Biochemistry
- Structural basis for converting a general transcription factor into an operon-specific virulence regulator (2007)
- Molecular Cell
- Two soluble pyrophosphatases in Vibrio cholerae: Transient redundancy or enduring cooperation? (2006)
- Биохимия / Biochemistry
- Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity (2005)
- Biochemistry
- Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum (2004)
- Journal of Biological Chemistry
- A lysine substitute for K+. A460K mutation eliminates K+ dependence in H+-pyrophosphatase of Carboxydothermus hydrogenoformans. (2002)
- Journal of Biological Chemistry
