Georgy Belogurov
PhD
gebelo@utu.fi +358 29 450 4775 +358 50 475 7149 Tykistökatu 6 Turku : 6057 |
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Ph.D. - University of Turku, Dept. of Biochemistry, Finland, 2005
Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009
Principal investigator - University of Turku, Dept. of Biochemistry, Finland, 2009-2020
Principal investigator - University of Turku, Dept. of Life Technologies, Finland, 2020-
Associate Professor - University of Turku, Dept. of Life Technologies, Finland, 2023-
The properties of a cell are determined by the information encoded in its genome. Understanding how such information is differentially and dynamically retrieved in response to environmental changes and cellular needs is a major challenge facing molecular biology. The focal point of our research is a multisubunit RNA polymerase, the enzyme that carries out the first step in gene expression, synthesis of RNA. We study several classes of RNA polymerases with the aim of understanding the fundamental aspects of transcription regulation, catalytic mechanism, and developing medically relevant transcription inhibitors.
Molecular Biology, Bioproduction, Bioinformatics, Enzyme kinetics
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- Concerted transformation of a hyper-paused transcription complex and its reinforcing protein (2024)
- Nature Communications
- Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates (2024)
- Journal of Biological Chemistry
- Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases (2022) Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.
- Real-Time Single-Molecule Studies of RNA Polymerase–Promoter Open Complex Formation Reveal Substantial Heterogeneity Along the Promoter-Opening Pathway (2022)
- Journal of Molecular Biology
- The role of the maleimide ring system on the structure-activity relationship of showdomycin (2022)
- European Journal of Medicinal Chemistry
- Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho (2021)
- Science
- The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
- Role of the trigger loop in translesion RNA synthesis by bacterial RNA polymerase (2020)
- Journal of Biological Chemistry
- The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling (2020)
- Nature Communications
- Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
- Oxazinomycin arrests RNA polymerase at the polythymidine sequences (2019)
- Nucleic Acids Research
- The Mechanisms of Substrate Selection, Catalysis, and Translocation by the Elongating RNA Polymerase (2019)
- Journal of Molecular Biology
- Active site closure stabilizes the backtracked state of RNA polymerase (2018)
- Nucleic Acids Research
- Locking the nontemplate DNA to control transcription (2018)
- Molecular Microbiology
- Structural basis of RNA polymerase I stalling at UV light-induced DNA damage (2018)
- Proceedings of the National Academy of Sciences of the United States of America
- Uneven Braking Spins RNA Polymerase into a Pause (2018)
- Molecular Cell
- Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
- GreA and GreB Enhance Expression of Escherichia coli RNA Polymerase Promoters in a Reconstituted Transcription–Translation System (2016)
- ACS Synthetic Biology
- Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases (2016)
- Nucleic Acids Research
- NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble (2016)
- eLife
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