Georgy Belogurov
PhD
gebelo@utu.fi +358 29 450 4775 +358 50 475 7149 Tykistökatu 6 Turku Office: 6057 ORCID identifier: https://orcid.org/0000-0002-3070-6843 |
Areas of expertise
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Biography
Ph.D. - University of Turku, Dept. of Biochemistry, Finland, 2005
Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009
Principal investigator - University of Turku, Dept. of Biochemistry, Finland, 2009-2020
Principal investigator - University of Turku, Dept. of Life Technologies, Finland, 2020-
Associate Professor - University of Turku, Dept. of Life Technologies, Finland, 2023-
Research
The properties of a cell are determined by the information encoded in its genome. Understanding how such information is differentially and dynamically retrieved in response to environmental changes and cellular needs is a major challenge facing molecular biology. The focal point of our research is a multisubunit RNA polymerase, the enzyme that carries out the first step in gene expression, synthesis of RNA. We study several classes of RNA polymerases with the aim of understanding the fundamental aspects of transcription regulation, catalytic mechanism, and developing medically relevant transcription inhibitors.
Teaching
Molecular Biology, Bioproduction, Bioinformatics, Enzyme kinetics
Publications 
1 of 3
- Concerted transformation of a hyper-paused transcription complex and its reinforcing protein (2024)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates (2024)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases (2022) Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.
(A3 Refereed book chapter or chapter in a compilation book) - Real-Time Single-Molecule Studies of RNA Polymerase–Promoter Open Complex Formation Reveal Substantial Heterogeneity Along the Promoter-Opening Pathway (2022)
- Journal of Molecular Biology
(A1 Refereed original research article in a scientific journal) - The role of the maleimide ring system on the structure-activity relationship of showdomycin (2022)
- European Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho (2021)
- Science
(A1 Refereed original research article in a scientific journal) - The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Role of the trigger loop in translesion RNA synthesis by bacterial RNA polymerase (2020)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling (2020)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Oxazinomycin arrests RNA polymerase at the polythymidine sequences (2019)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - The Mechanisms of Substrate Selection, Catalysis, and Translocation by the Elongating RNA Polymerase (2019)
- Journal of Molecular Biology
(A2 Refereed review article in a scientific journal ) - Active site closure stabilizes the backtracked state of RNA polymerase (2018)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Locking the nontemplate DNA to control transcription (2018)
- Molecular Microbiology
(A1 Refereed original research article in a scientific journal) - Structural basis of RNA polymerase I stalling at UV light-induced DNA damage (2018)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - Uneven Braking Spins RNA Polymerase into a Pause (2018)
- Molecular Cell
(B1 Non-refereed article in a scientific journal) - Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
(A1 Refereed original research article in a scientific journal) - GreA and GreB Enhance Expression of Escherichia coli RNA Polymerase Promoters in a Reconstituted Transcription–Translation System (2016)
- ACS Synthetic Biology
(A1 Refereed original research article in a scientific journal) - Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases (2016)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble (2016)
- eLife
(A1 Refereed original research article in a scientific journal)
UTU Research Portal