Matej Oresic
 Ph.D.


matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku


ORCID-tunnistehttps://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar



Asiantuntijuusalueet
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Biografia

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Tutkimus

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



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  • Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids  (2022)  
    • Clinical Nutrition
     Gürdeniz Gözde, Uusitupa Matti, Hermansen Kjeld, Savolainen Markku J, Schwab Ursula, Kolehmainen Marjukka, Brader Lea, Cloetens Lieselotte, Herzig Karl-Heinz, Hukkanen Janne, Rosqvist Fredrik, Ulven Stine Marie, Gunnarsdóttir Ingibjörg, Thorsdottir Inga, Oresic Matej, Poutanen Kaisa S, Risérus U, Åkesson Björn, Dragsted Lars Ove
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Correction: Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling (Journal of Proteome Research (2012) 11:2 (850-860) DOI: 10.1021/pr200685r)  (2022)  
    • Journal of Proteome Research
     Brockmöller Scarlet F., Bucher Elmar, Müller Berit M., Budczies Jan, Hilvo Mika, Griffin Julian L., Orešič Matej, Kallioniemi Olli, Iljin Kristiina, Loibl Sibylle, Darb-Esfahani Silvia, Sinn Bruno V., Klauschen Frederick, Prinzler Judith, Bangemann Nikola, Ismaeel Fakher, Fiehn Oliver, Dietel Manfred, Denkert Carsten
    (
    O2 Muu julkaisu )


  • Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes  (2022)  
    • Cell Reports Medicine
     Lamichhane Santosh, Sen Partho, Dickens Alex M., Alves Marina Amaral, Härkönen Taina, Honkanen Jarno, Vatanen Tommi, Xavier Ramnik J., Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study  (2022)  
    • Cannabis and Cannabinoid Research
     Chester Lucy A., Englund Amir, Chesney Edward, Oliver Dominic, Wilson Jack, Sovi Simina, Dickens Alex M., Oresic Matej, Linderman Tuomas, Hodsoll John, Minichino Amedeo, Strang John, Murray Robin M., Freeman Tom P., McGuire Philip
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease  (2022)  
    • Journal of Hepatology
     Sen Partho, Qadri Sami, Luukkonen Panu K, Ragnarsdottir Oddny, McGlincheyAidan , Jäntti Sirkku, Juuti Anne, Arola Johanna, Schlezinger Jennifer J, Webster Thomas F, Orešič Matej, Yki-Järvinen Hannele, Hyötyläinen Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice  (2022)  
    • Metabolomics
     Sinioja Tim, Bodin Johanna, Duberg Daniel, Dirven Hubert, Berntsen Hanne Friis, Zimmer Karin, Nygaard Unni C., Orešič Matej, Hyötyläinen Tuula
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers  (2022)  
    • Cells
     Kobeissy Firas, Kobaisi Abir, Peng Wenjing, Barsa Chloe, Goli Mona, Sibahi Ahmad, El Hayek Samer, Abdelhady Samar, Ali Haidar Muhammad, Sabra Mirna, Oresic Matej, Logroscino Giancarlo, Mondello Stefania, Eid, Ali H.Y, Mechref Yehia
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life  (2022)  
    • Frontiers in Nutrition
     Lamichhane Santosh, Siljander Heli, Salonen Marja, Ruohtula Terhi, Virtanen Suvi M., Ilonen Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance  (2022)  
    • JHEP Reports
     Katherine Johnson, Peter J Leary, Olivier Govaere, Matthew J Barter, Sarah H Charlton, Simon J Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M Julia Brosnan, Jeremy F Cobbold, Mattias Ekstedt, Guruprasad P Aithal, Karine Clément, Jörn M Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M Anstee, Ann K Daly, on behalf of the
    LITMUS Consortium Investigators,

    James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Lipidomics in nutrition research  (2022)  
    • Current Opinion in Clinical Nutrition and Metabolic Care
     Castro-Alves Victora, Orešič Matej, Hyötyläinen Tuulia
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)



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