Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Recent advances towards mass spectrometry-based clinical lipidomicsIncreased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance (2023)
- Current Opinion in Chemical BiologyJHEP Reports
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes (2023)
- Scientific ReportsJHEP Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice (2023)
- Nature MicrobiologyFrontiers in Molecular Biosciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipidsPermutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022)
- Clinical NutritionEpigenetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Correction: Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling (Journal of Proteome Research (2012) 11:2 (850-860) DOI: 10.1021/pr200685r)Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort (2022)
- Journal of Proteome Research
(O2 Muu julkaisu ) - Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes (2022)
- Cell Reports MedicineSchizophrenia Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study (2022)
- Cannabis and Cannabinoid ResearchiScience
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease (2022)
- Journal of Hepatology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice (2022)
- Metabolomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers (2022)
- Cells
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life (2022)
- Frontiers in Nutrition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2022)
LITMUS Consortium Investigators,
James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Lipidomics in nutrition research (2022)
- Current Opinion in Clinical Nutrition and Metabolic Care
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease (2022)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Metabolomic and proteomic profiling in bipolar disorder patients revealed potential molecular signatures related to hemostasis (2022)
- Metabolomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Multi-omics: Trends and applications in clinical research (2022)
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - (2022)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2022)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease (2022)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum metabolome associated with severity of acute traumatic brain injury (2022)
- Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



