Matej Oresic
 Ph.D.


matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku


ORCID-tunnistehttps://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar



Asiantuntijuusalueet
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Biografia

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Tutkimus

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



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  •   (2024)  
    • Analytical ChemistryDiabetologia
     Isokääntä, Heidi; Pinto da Silva, Lucas; Karu, Naama; Kallonen, Teemu; Aatsinki, Anna-Katariina; Hankemeier, Thomas; Schimmel, Leyla; Diaz, Edgar; Hyötyläinen, Tuulia; Dorrestein, Pieter C.; Knight, Rob; Orešič, Matej; Kaddurah-Daouk, Rima; Dickens, Alex M.; Lamichhane, Santosh
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards  (2024)  
    • Nature CommunicationsCell Reports Medicine
     Torta, Federico; Hoffmann, Nils; Burla, Bo; Alecu, Irina; Arita, Makoto; Bamba, Takeshi; Bennett, Steffany A. L.; Bertrand-Michel, Justine; Brügger, Britta; Cala, Mónica P.; Camacho-Muñoz, Dolores; Checa, Antonio; Chen, Michael; Chocholoušková, Michaela; Cinel, Michelle; Chu-Van, Emeline; Colsch, Benoit; Coman, Cristina; Connell, Lisa; Sousa Bebiana C.; Dickens, Alex M.; Fedorova, Maria; Eiríksson, Finnur Freyr; Gallart-Ayala, Hector; Ghorasaini, Mohan; Giera, Martin; Guan, Xue Li; Haid, Mark; Hankemeier, Thomas; Harms, Amy; Höring, Marcus; Holčapek, Michal; Hornemann, Thorsten; Hu, Chunxiu; Hülsmeier, Andreas J.; Huynh, Kevin; Jones, Christina M.; Ivanisevic, Julijana; Izumi, Yoshihiro; Köfeler, Harald C.; Lam, Sin Man; Lange, Mike; Lee, Jong Cheol; Liebisch, Gerhard; Lippa, Katrice; Lopez-Clavijo, Andrea F.; Manzi, Malena; Martinefski, Manuela R.; Math, Raviswamy G. H.; Mayor, Satyajit; Meikle, Peter J.; Monge, María Eugenia; Moon, Myeong Hee; Muralidharan, Sneha; Nicolaou, Anna; Nguyen-Tran, Thao; O’Donnell, Valerie B.; Orešič, Matej; Ramanathan, Arvind; Riols, Fabien; Saigusa, Daisuke; Schock, Tracey B.; Schwartz-Zimmermann, Heidi; Shui, Guanghou; Singh, Madhulika; Takahashi, Masatomo; Thorsteinsdóttir, Margrét; Tomiyasu, Noriyuki; Tournadre, Anthony; Tsugawa, Hiroshi; Tyrrell, Victoria J.; van der Gugten, Grace; Wakelam, Michael O.; Wheelock, Craig E.; Wolrab, Denise; Xu, Guowang; Xu, Tianrun; Bowden, John A.; Ekroos, Kim; Ahrends, Robert; Wenk, Markus R.
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity  (2024)  
    • Environment International
     Sen, Partho; Fan, Yong; Schlezinger, Jennifer J.; Ehrlich, Stanislav D.; Webster, Thomas F.; Hyötyläinen, Tuulia; Pedersen, Oluf; Orešič, Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Hepatic glucose production is increased in MASH with significant fibrosis even in absence of diabetes  (2024)  
       Sabatini, S.; Sen, P.; Carli, F.; Pezzica, S.; Lembo, E.; Rosso, C.; Daly, A.; Cockel, S.; Govaere, O.; Hyotylainen, T.; Mingrone, G.; Bugianesi, E.; Anstee, Q. M.; Oresic, M.; Gastaldelli, A.
      (
      Abstrakti)


    • Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis  (2024)  
         Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      • Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease  (2024)  
        • Nature Communications
         Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine; Andersen, Svend; Noble, Alexandra J.; Dorn-Rasmussen, Maria; Bazov, Igor; Perminow, Gøri; Opheim, Randi; Detlie, Trond Espen; Huppertz-Hauss, Gert; Hedin, Charlotte R. H.; Carlson, Marie; Öhman, Lena; Magnusson, Maria K.; Keita, Åsa V.; Söderholm, Johan D.; D’Amato, Mauro; Orešič, Matej; Wewer, Vibeke; Satsangi, Jack; Lindqvist, Carl Mårten; Burisch, Johan; Uhlig, Holm H.; Repsilber, Dirk; Hyötyläinen, Tuulia; Høivik, Marte Lie; Halfvarson, Jonas
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      •   (2024)  
        • Environmental Science and TechnologyCell
         Hyötyläinen, Tuulia; Ghaffarzadegan, Tannaz; Karthikeyan, Bagavathy Shanmugam; Triplett, Eric; Orešič, Matej; Ludvigsson, Johnny
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      • Infant microbes and metabolites point to childhood neurodevelopmental disorders  (2024)  
           Ahrens, Angelica P.; Hyötyläinen, Tuulia; Petrone, Joseph R.; Igelström, Kajsa; George, Christian D.; Garrett, Timothy J.; Orešič, Matej; Triplett, Eric W.; Ludvigsson, Johnny
          (
          A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


        • In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional study  (2024)  
          • The Lancet Planetary Health
           Hyötyläinen, Tuulia; McGlinchey, Aidan; Salihovic, Samira; Schubert, Antonia; Douglas, Alex; Hay, David C.; O'Shaughnessy, Peter J.; Iredale, John P.; Shaw, Sophie; Fowler, Paul A.; Orešič, Matej
          (
          A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


        • Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA  (2024)  
          • Proceedings of the National Academy of Sciences of the United States of America
           Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
          (
          A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



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