Matej Oresic
 Ph.D.


matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku


ORCID-tunnistehttps://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar



Asiantuntijuusalueet
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Biografia

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Tutkimus

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



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  • Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study  (2022)  
    • Cannabis and Cannabinoid ResearchiScience
     Chester Lucy A., Englund Amir, Chesney Edward, Oliver Dominic, Wilson Jack, Sovi Simina, Dickens Alex M., Oresic Matej, Linderman Tuomas, Hodsoll John, Minichino Amedeo, Strang John, Murray Robin M., Freeman Tom P., McGuire Philip
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease  (2022)  
    • Journal of Hepatology
     Sen Partho, Qadri Sami, Luukkonen Panu K, Ragnarsdottir Oddny, McGlincheyAidan , Jäntti Sirkku, Juuti Anne, Arola Johanna, Schlezinger Jennifer J, Webster Thomas F, Orešič Matej, Yki-Järvinen Hannele, Hyötyläinen Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic miceUmbilical cord blood DNA methylation in children who later develop type 1 diabetes  (2022)  
    • MetabolomicsDiabetologiaFASEB Journal
     Sinioja Tim, Bodin Johanna, Duberg Daniel, Dirven Hubert, Berntsen Hanne Friis, Zimmer Karin, Nygaard Unni C., Orešič Matej, Hyötyläinen Tuula
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers  (2022)  
    • Cells
     Kobeissy Firas, Kobaisi Abir, Peng Wenjing, Barsa Chloe, Goli Mona, Sibahi Ahmad, El Hayek Samer, Abdelhady Samar, Ali Haidar Muhammad, Sabra Mirna, Oresic Matej, Logroscino Giancarlo, Mondello Stefania, Eid, Ali H.Y, Mechref Yehia
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life  (2022)  
    • Frontiers in NutritionAtherosclerosis
     Lamichhane Santosh, Siljander Heli, Salonen Marja, Ruohtula Terhi, Virtanen Suvi M., Ilonen Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance  (2022)  
    • JHEP Reports
     Katherine Johnson, Peter J Leary, Olivier Govaere, Matthew J Barter, Sarah H Charlton, Simon J Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M Julia Brosnan, Jeremy F Cobbold, Mattias Ekstedt, Guruprasad P Aithal, Karine Clément, Jörn M Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M Anstee, Ann K Daly, on behalf of the
    LITMUS Consortium Investigators,

    James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Lipidomics in nutrition research  (2022)  
    • Current Opinion in Clinical Nutrition and Metabolic CareActa Physiologica
     Castro-Alves Victora, Orešič Matej, Hyötyläinen Tuulia
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease  (2022)  
    • JHEP Reports
     McGlinchey Aidan J, Govaere Oivier, Geng Dawei, Ratziu Vlad, Allison Michael, Bousier Jerome, Petta Salvatore, de Oliviera Claudia, Bugianesi Elisabetta, Schattenberg Jörn M, Daly Ann K, Hyötyläinen Tuulia, Anstee Quentin M, Orešič Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Metabolomic and proteomic profiling in bipolar disorder patients revealed potential molecular signatures related to hemostasis  (2022)  
    • Metabolomics
     Caracho Ribeiro Henrique, Sen Partho, Dickens Alex, Santa Cruz Elisa Castañeda, Orešič Matej, Sussulini Alessandra
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Multi-omics: Trends and applications in clinical research  (2022)  
    • Frontiers in Molecular Biosciences
     Sussulini Alessandra, Xia Jianguo, Oresic Matej
    (
    B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä )


  • Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples  (2022)  
    • Epigenetics
     Laajala Essi, Halla-Aho Viivi, Grönroos Toni, Kalim Ubaid Ullah, Vähä-Mäkilä Mari, Nurmio Mirja, Kallionpää Henna, Lietzén Niina, Mykkänen Juha, Rasool Omid, Toppari Jorma, Oresic Matej, Knip Mikael, Lund Riikka, Lahesmaa Riitta, Lähdesmäki HarriA1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

  • Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort  (2022)  
    • Schizophrenia Research
     Yin Xiaofei, Mongan David, Cannon Mary, Zammit Stanley, Hyötyläinen Tuulia, Orešič Matej, Brennan Lorraine, Cotter David R
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease  (2022)  
       Sen Partho, Govaere Olivier, Sinioja Tim, McGlinchey Aidan, Geng Dawei, Ratziu Vlad, Bugianesi Elisabetta, Schattenberg Jörn M, Vidal-Puig Antonio, Allison Michael, Cockell Simon, Daly Ann K, Hyötyläinen Tuulia, Anstee Quentin M, Orešič Matej
      (
      A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


    • Serum metabolome associated with severity of acute traumatic brain injury  (2022)  
      • Nature Communications
       Thomas Ilias, Dickens Alex M, Posti Jussi P, Czeiter Endre, Duberg Daniel, Sinioja Tim, Kråkström Matilda, Helmrich Isabel RA Retel, Wang Kevin KW, Maas Andrew IR, Steyerberg Ewout W, Menon David K, Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Orešič Matej; Group author: CENTER-TBI Participants and Investigators
      (
      A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


    • The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles  (2022)  
         Lahelma Mari, Qadri Sami, Ahlholm Noora, Porthan Kimmo, Ruuth Maija, Juuti Anne, Orešič Matej, Hyötyläinen Tuulia, Öörni Katariina, Yki-Järvinen Hannele
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      • Traumatic brain injury: progress and challenges in prevention, clinical care, and research  (2022)  
        • Lancet Neurology
         Maas Andrew IR, Menon David K, Manley Geoffrey T, Abrams Mathew, Åkerlund Cecilia, Andelic Nada, Aries Marcel, Bashford Tom, Bell Michael J, Bodien Yelena G, Brett Benjamin L, Büki András, Chesnut Randall M, Citerio Giuseppe, Clark David, Clasby Betony, Cooper D Jamie, Czeiter Endre, Czosnyka Marek, Dams-O'Connor Kristen, De Keyser Véronique, Diaz-Arrastia Ramon, Ercole Ari, van Essen Thomas A, Falvey Éanna, Ferguson Adam R, Figaji Anthony, Fitzgerald Melinda, Foreman Brandon, Gantner Dashiell, Gao Guoyi, Giacino Joseph, Gravesteijn Benjamin, Guiza Fabian, Gupta Deepak, Gurnell Mark, Haagsma Juanita A, Hammond Flora M, Hawryluk Gregory, Hutchinson Peter, van der Jagt Mathieu, Jain Sonia, Jain Swati, Jiang Ji-yao, Kent Hope, Kolias Angelos, Kompanje Erwin JO, Lecky Fiona, Lingsma Hester F, Maegele Marc, Majdan Marek, Markowitz Amy, McCrea Michael, Meyfroidt Geert, Mikolić Ana, Mondello Stefania, Mukherjee Pratik, Nelson David, Nelson Lindsay D, Newcombe Virginia, Okonkwo David, Orešič Matej, Peul Wilco, Pisică Dana, Polinder Suzanne, Ponsford Jennie, Puybasset Louis, Raj Rahul, Robba Chiara, Røe Cecilie, Rosand Jonathan, Schueler Peter, Sharp David J, Smielewski Peter, Stein Murray B, von Steinbüchel Nicole, Stewart William, Steyerberg Ewout W, Stocchetti Nino, Temkin Nancy, Tenovuo Olli, Theadom Alice, Thomas Ilias, Espin Abel Torres, Turgeon Alexis F, Unterberg Andreas, Van Praag Dominique, van Veen Ernest, Verheyden Jan, Vande Vyvere Thijs, Wang Kevin KW, Wiegers Eveline JA, Williams W Huw, Wilson Lindsay, Wisniewski Stephen R, Younsi Alexander, Yue John K, Yuh Esther L, Zeiler Frederick A, Zeldovich Marina, Zemek Roger; for the InTBIR Participants and Investigators
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      •   (2022)  
           Laajala Essi, Kalim Ubaid U, Grönroos Toni, Rasool Omid, Halla-aho Viivi, Konki Mikko, Kattelus Roosa, Mykkänen Juha, Nurmio Mirja, Vähä-Mäkilä Mari, Kallionpää Henna, Lietzen Niina, Ghimire Bishwa R, Laiho Asta, Hyöty Heikki, Elo Laura L, Ilonen Jorma, Knip Mikael, Lund Riikka J, Orešič Matej, Veijola Riitta, Lähdesmäki Harri, Toppari Jorma, Lahesmaa Riitta
          (
          A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


        • 1‐deoxyceramides – key players in lipotoxicity and progression to type 2 diabetes?  (2021)  
             Sen Partho, Hyötyläinen Tuulia, Orešič Matej
            (
            B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä )


          • Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism  (2021)  
            • British Journal of Pharmacology
             Karpale Mikko, Käräjamäki Aki J, Kummu Outi, Gylling Helena, Hyötyläinen Tuulia, Oresic Matej, Tolonen Ari, Hautajärvi Heidi, Savolainen Markku J, Ala-Korpela Mika, Hukkanen Janne, Hakkola Jukka
            (
            A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


          • Allostatic hypermetabolic response in PGC1 alpha/beta heterozygote mouse despite mitochondrial defects2021
               Rodriguez-Cuenca Sergio, Lelliot Christopher J, Campbell Mark, Peddinti Gopal, Martinez-Uña Maite, Ingvorsen Camilla, Dias Ana Rita, Relat Joana, Mora Silvia, Hyötyläinen Tuulia, Zorzano Antonio, Orešič Matej, Bjursell Mikael, Bohlooly-Y Mohammad, Lindén Daniel, Vidal-Puig Antonio
              (
              A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



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