Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (2015)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Erratum to: Coordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (vol 11, pg 1587, 2015) (2015)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function (2015)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Optimizing the lipidomics workflow for clinical studies-practical considerations (2015)
- Analytical and Bioanalytical Chemistry
(A2 Refereed review article in a scientific journal ) - Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Self-organization and missing values in SOM and GTM (2015)
- Neurocomputing
(A1 Refereed original research article in a scientific journal) - Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants (2015)
- Metabolism
(A1 Refereed original research article in a scientific journal) - The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes (2015)
- Cell Host and Microbe
(A1 Refereed original research article in a scientific journal) - The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity (2015)
- British Journal of Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - The influence of sample collection methodology and sample preprocessing on the blood metabolic profile (2015)
- Bioanalysis
(A1 Refereed original research article in a scientific journal) - The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity (2014)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Systems biology strategies to study lipidomes in health and disease (2014)
- Progress in Lipid Research
(A2 Refereed review article in a scientific journal ) - Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes (2013)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol (2013)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids (2013)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Evidence from an Integrated Analysis Combining Genomics, Transcriptomics, and Lipidomics Implies a Causal Role of Inflammation for Low HDL-C (2012)
- Circulation
(Other publication) - Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression (2011)
- Cancer Research
(A1 Refereed original research article in a scientific journal) - Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes (2008)
- Journal of Experimental Medicine
(A1 Refereed original research article in a scientific journal) - Improving identification of differentially expressed genes by integrative analysis of Affymetrix and Illumina arrays. (2006)
- OMICS
(A1 Refereed original research article in a scientific journal)