Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI) (2016)
- Metabolism
(A1 Refereed original research article in a scientific journal) - Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism (2016)
- Journal of Lipid Research
(A1 Refereed original research article in a scientific journal) - Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites (2016)
- Journal of Nutritional Biochemistry
(A1 Refereed original research article in a scientific journal) - Modeling strategies to study metabolic pathways in progression to type 1 diabetes - Challenges and opportunities (2016)
- Archives of Biochemistry and Biophysics
(A2 Refereed review article in a scientific journal ) - Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites (2016)
- Clinical Gastroenterology and Hepatology
(A1 Refereed original research article in a scientific journal) - Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis (2016)
- Translational Psychiatry
(A1 Refereed original research article in a scientific journal) - The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes (vol 17, pg 260, 2015) (2016)
- Cell Host and Microbe
(A1 Refereed original research article in a scientific journal) - The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans (2016)
- Journal of Hepatology
(Other publication) - Altered lipid metabolism preceding onset of islet autoimmunity and type 1 diabetes (2015)
- Diabetologia
(Other publication) - Analytical Lipidomics in Metabolic and Clinical Research (2015)
- Trends in Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Bioactive lipids dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease (2015)
- Diabetologia
(Other publication) - Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2 (2015)
- Journal of Hepatology
(A1 Refereed original research article in a scientific journal) - COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (2015)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Erratum to: Coordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (vol 11, pg 1587, 2015) (2015)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function (2015)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Optimizing the lipidomics workflow for clinical studies-practical considerations (2015)
- Analytical and Bioanalytical Chemistry
(A2 Refereed review article in a scientific journal ) - Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Self-organization and missing values in SOM and GTM (2015)
- Neurocomputing
(A1 Refereed original research article in a scientific journal) - Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants (2015)
- Metabolism
(A1 Refereed original research article in a scientific journal)



