Heli Harvala
 MD, PhD, EUPHEM Alumni, FRCPath

Virology

heli.harvala@utu.fi




ORCID-tunnistehttps://orcid.org/0000-0001-9154-4190





Asiantuntijuusalueet
Virology; Clinical Virology; Public Health Virology; Transfusion Virology

Biografia

Heli Harvala was appointed as a Professor of Virology at the Institute of Biomedicine, University of Turku, Finland in September, 2024. 

She graduated in Medicine, obtained a MSc in Organic Chemistry and a PhD in Virology at the University of Turku, Finland, in 2003. Subsequently she completed her Medical Virology training in Edinburgh and became a Fellow of the Royal College of Pathologists in 2015. During that time, she joined the European Public Health Microbiology fellowship programme at the Public Health Agency of Sweden for two years before returning back to the UK. Over the last ten years, she has combined her work as a Consultant Medical Virologist with clinical, transfusion and public health related virology research.



Tutkimus

She is a co-founder of the European Non-Polio Enterovirus Network (ENPEN) which evaluates the importance of enterovirus infections and monitors for their emergence together with collaborators from over 30 European countries. During COVID-19 pandemic, she was involved with setting up SARS-CoV-2 testing of convalescent plasma donors in England, and the related international REMAP-CAP trial. She also has wide interests in molecular epidemiology and next generation sequencing, and is involved with investigations into how next generation sequencing could be used to enhance the effectiveness of microbiological donation screening.

She leads the Blood Safety research team within the NIHR funded Blood and Transplant Research Unit at the University of Oxford. This research focuses on transfusion transmitted viral infections aiming to improve our understanding of current risks and preparedness for emerging pathogens. She also recently led the work in identifying occult hepatitis B infections as a blood transfusion risk in England and has done pioneering work to investigate pre-exposure prophylaxis use among syphilis infected blood donors. While these activieis continue, she is currently establishing her research group at the University of Turku.

Prof Harvala is widely published in the field of medical, transfusion and public health virology (over 130 peer reviewed publications, h-index 48). She is an executive committee member of European Society for Clinical Virology and the programme committee member for the European Society for Clinical Microbiology and infectious Diseases. She was recently appointed to the WHO European Region Commission for the Certification of Poliomyelitis Eradication, and previously chaired the WHO R&D Blueprint group on Picornaviruses, the Microbiology Specialist Interest Group for the British Blood Transfusion Society, the Panel of Senior Virology Examiners for the RCPath and the Standing Advisory Committee for Transfusion Transmitted Infections.   



Opetus

She is currently involved in the undergraduate teaching of medical and biomedical students, being responsible for the virology part of that. She has previously been involved in the Undergraduate teaching at the University College of London, University of Edinburgh, the University of Oulu and at the University of Turku. She is also actively engaging with Postgraduate teaching by supervising both PhD and MSc students, and has undertaken PhD Supervisors training at the University of Oxford. Furthermore, she has extensive experience in Clinical Virology specialty training; she has been trained educational supervisor in Clinical Virology since 2016 and trained Royal College of Pathologist Examiner in Clinical Virology since 2017.

Her interest includes developing training further and as an example, she developed a new three-day module in Phylogenetics and Bioinformatics for European Centre for Disease Control (ECDC) Stockholm with the microbiological cases studies in 2016. Subsequently, she led the developing and delivering this for the ECDC summer schools in Stockholm, 2016 and 2017, and for the ECDC EPIET/EUPHEM fellows in Berlin, 2017 and 2018.



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    • A need for confirmatory testing of isolated HBcAb-positive results in screening programs  (2024)   Fu MX, Simmonds P, Harvala H


    • An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NATInternational review of blood donation screening for anti-HBc and occult hepatitis B virus infection  (2024)  
      • Vox SanguinisTransfusion
       Faddy HM, Osiowy C, Custer B, Busch M, Stramer SL, Dean MM, Acutt J, Viennet E, van de Laar T, Tsoi WC, Styles C, Kiely P, Margaritis A, Kwon SY, Qiu Y, Deng X, Lewin A, Jørgensen SW, Erikstrup C, Juhl D, Sauleda S, Camacho Rodriguez BA, Soto Coral LJC, Gaviria García PA, Oota S, O'Brien SF, Wendel S, Castro E, Navarro Pérez L, Harvala H, Davison K, Reynolds C, Jarvis L, Grabarczyk P, Kopacz A, Łętowska M, O'Flaherty N, Young F, Williams P, Burke L, Chua SS, Muylaert A, Page I, Jones A, Niederhauser C, Vermeulen M, Laperche S, Gallian P, Satake M, Addas-Carvalho M, Blanco S, Gallego SV, Seltsam A, Weber-Schehl M, Al-Riyami AZ, Al Maamari K, Alawi FB, Pandey HC, França RA, Charlewood R, Virology and Surveillance, Risk Assessment and Policy subgroups of the ISBT WP‐TTID
      (
      )


    •   (2024)  
      • Journal of General VirologyEmerging Infectious Diseases
       Couderé, Karen; Benschop, Kimberley S.M.; Koen, Gerrit; van Eijk Hetty; Harvala, Heli; Bailly, Jean-Luc; Bessaud, Maël; Kamau, Everlyn; Simon, Isabelle; Joffret, Marie-Line; Nikolaeva-Glomb, Lubomira; Georgieva, Irina; Stoyanova, Asya; Diedrich, Sabine; Böttcher, Sindy; Cabrerizo, Maria; Tabain, Irena; Hruškar, Željka; Stevanović, Vladimir; Susi, Petri; Hietanen, Eero; Palminha, Paula; Rainetová, Petra; Baicus, Anda; Kristensen, Maartje; Pajkrt, Dasja; Murk, Jean-Luc; Wolthers, Katja C.; and European non-polio enterovirus network
      (
      A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


    •   (2024)  
      • Scientific ReportsLancet regional health - Europe
       Verbrugghe C, Wouters E, Devloo R, Nurmi V, Seghers S, De Bleser D, Harvala H, Compernolle V, Feys HB


    • Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next?  (2024)  
      • Reviews in Medical VirologyJournal of Medical Virology
       Fu, Michael X; Simmonds, Peter; Andersson, Monique; Harvala, Heli
      (
      A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


    • Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups  (2024)  
      • Vox Sanguinis
       Fu MX, Ingram J, Roberts C, Nurmi V, Watkins E, Dempsey N, Golubchik T, Breuer J, Brailsford S, Irving WL, Andersson M, Simmonds P, Harvala H


    • Castanet: a pipeline for rapid analysis of targeted multi-pathogen genomic dataAbsence of detectable monkeypox virus DNA in 11,000 English blood donations during the 2022 outbreak2024
      • BioinformaticsTransfusion
       Mayne R, Secret S, Geoghegan C, Trebes A, Kean K, Reid K, Lin GL, Ansari MA, de Cesare M, Bonsall D, Elliott I, Piazza P, Brown A, Bray J, Knight JC, Harvala H, Breuer J, Simmonds P, Bowden RJ, Golubchik T


    • Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination2024
      • VaccinesNature Medicine
       Mosavie M, Rynne J, Fish M, Smith P, Jennings A, Singh S, Millar J, Harvala H, Mora A, Kaloyirou F, Griffiths A, Hopkins V, Washington C, Estcourt LJ, Roberts D, Shankar-Hari M


    • Characterising the molecular epidemiology of human parechovirus in young infants in the UK and Canada  (2024)  
      • Journal of Clinical Virology
       Kadambari S, Harvala H, Nguyen D, Sadarangani M, Martin NG, Al-Rawahi GN, Sekirov I, Defres S, Solomon T, Golubchik T, Bowden R, Pollard AJ, Simmonds P


    • Enterovirus A71 and coxsackievirus A6 circulation in England, UK, 2006-2017: A mathematical modelling study using cross-sectional seroprevalence data  (2024)  
      • PLoS Pathogens
       Kamau E, Lambert B, Allen DJ, Celma C, Beard S, Harvala H, Simmonds P, Grassly NC, Pons-Salort M


    • Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study  (2024)  
      • Journal of Infectious Diseases
       Simoes MP, Hodcroft EB, Simmonds P, Albert J, Alidjinou EK, Ambert-Balay K, Andrés C, Antón A, Auvray C, Bailly JL, Baldanti F, Bastings C, Beard S, Berengua C, Berginc N, Bloemen M, Blomqvist S, Bosma F, Böttcher S, Bubba L, Buderus S, Cabrerizo M, Calvo C, Celma C, Ceriotti F, Clark G, Costa I, Coste-Burel M, Couderé K, Cremer J, Del Cuerpo Casas M, Daehne T, de Beer J, de Ceano-Vivas M, De Gascun C, de Rougemont A, Dean J, Dembinski JL, Diedrich S, Diez-Domingo J, Dillner L, Dorenberg DH, Ducancelle A, Dudman S, Dyrdak R, Eis-Huebinger AM, Falces-Romero I, Farkas A, Feeney S, Fernandez-Garcia MD, Flipse J, Franck KT, Galli C, Garrigue I, Geeraedts F, Georgieva I, Giardina F, Guiomar R, Hauzenberger E, Heikens E, Henquell C, Hober D, Hönemann M, Howson-Wells H, Hruškar Ž, Ikonen N, Imbert B, Jansz AR, Jeannoël M, Jiřincová H, Josset L, Keeren K, Kramer-Lindhout N, Krokstad S, Lazrek M, Le Guillou-Guillemette H, Lefeuvre C, Lind A, Lunar MM, Maier M, Marque-Juillet S, McClure CP, McKenna J, Meijer A, Menasalvas Ruiz A, Mengual-Chuliá B, Midgley S, Mirand A, Molenkamp R, Montes M, Moreno-Docón A, Morley U, Murk JL, Navascués-Ortega A, Nijhuis R, Nikolaeva-Glomb L, Nordbø SA, Numanovic S, Oggioni M, Oñate Vergara E, Pacaud J, Pacreau ML, Panning M, Pariani E, Pekova L, Pellegrinelli L, Petrovec M, Pietsch C, Pilorge L, Piñeiro L, Piralla A, Poljak M, Prochazka B, Rabella N, Rahamat-Langendoen JC, Rainetova P, Reynders M, Riezebos-Brilman A, Roorda L, Savolainen-Kopra C, Schuffenecker I, Smeets LC, Stoyanova A, Stefic K, Swanink C, Tabain I, Tjhie J, Thouault L, Tumiotto C, Uceda Renteria S, Uršič T, Vallet S, Van Ranst M, Van Wunnik P, Verweij JJ, Vila J, Wintermans B, Wollants E, Wolthers KC, Xavier López-Labrador F, Fischer TK, Harvala H, Benschop KSM


    • Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses  (2024)  
      • Genome Medicine
       Buddle S, Forrest L, Akinsuyi N, Martin Bernal LM, Brooks T, Venturini C, Miller C, Brown JR, Storey N, Atkinson L, Best T, Roy S, Goldsworthy S, Castellano S, Simmonds P, Harvala H, Golubchik T, Williams R, Breuer J, Morfopoulou S, Torres Montaguth OE


    • International review of blood donation nucleic acid amplification testing  (2024)  
      • Vox Sanguinis
       Faddy HM, Osiowy C, Custer B, Busch M, Stramer SL, Adesina O, van de Laar T, Tsoi WC, Styles C, Kiely P, Margaritis A, Kwon SY, Qiu Y, Deng X, Lewin A, Jørgensen SW, Erikstrup C, Juhl D, Sauleda S, Camacho Rodriguez BA, Coral LJCS, Gaviria García PA, Oota S, O'Brien SF, Wendel S, Castro E, Navarro Pérez L, Harvala H, Davison K, Reynolds C, Jarvis L, Grabarczyk P, Kopacz A, Łętowska M, O'Flaherty N, Young F, Williams P, Burke L, Chua SS, Muylaert A, Page I, Jones A, Niederhauser C, Vermeulen M, Laperche S, Gallian P, Sawadogo S, Satake M, Gharehbaghian A, Addas-Carvalho M, Blanco S, Gallego SV, Seltsam A, Weber-Schehl M, Al-Riyami AZ, Al Maamari K, Alawi FB, Pandey HC, Mbanya D, França RA, Charlewood R, Virology and Surveillance; Risk Assessment and Policy subgroups of the ISBT Working Party on Transfusion‐transmitted Infectious Diseases
      (
      A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


    •   (2024)  
         Fu MX, Faddy HM, Candotti D, Groves J, Saa P, Styles C, Adesina O, Carrillo JP, Seltsam A, Weber-Schehl M, O'Brien SF, Drews SJ, Aidoo NB, Pajares ÁL, Perez LN, Deng X, van de Laar T, Laperche S, Lehtisalo R, Yilmaz S, Tsoi WC, Juhl D, Niederhauser C, Chenarsabz N, O'Flaherty N, Goto N, Satake M, Renaud C, Lewin A, Cloutier M, Sawadogo S, Reynolds C, Zhiburt E, Muylaert A, Van Gaever V, Garcia-Otalora MA, Jarvis L, Vermeulen M, Busch M, Blackmore S, Jones A, Brailsford S, Irving WL, Andersson M, Simmonds P, Harvala H, Virology subgroup of the ISBT WP‐TTID
        (
        A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


      • Parechovirus A Circulation and Testing Capacities in Europe, 2015-2021.  (2024)  
           Bubba L, Broberg EK, Fischer TK, Simmonds P, Harvala H, European Non-polio Enterovirus Network working group


        • Poliovirus circulation in the WHO European region, 2015-2022: a review of data from WHO's three core poliovirus surveillance systems  (2024)  
             Fischer TK, Johannesen CK, Benschop KSM, Berginc N, Saxentoff EV, Huseynov S, Hagan JE, Harvala H


          • Reconstruction of the historic time course of blood-borne virus contamination of clotting factor concentrates, 1974-1992.  (2024)  
               McClure CP, Kean K, Reid K, Mayne R, Fu MX, Rajendra P, Gates S, Breuer J, Harvala H, Golubchik T, Tarr AW, Irving WL, Makris M, Simmonds P


            • Why is polio still a concern, also in Europe?  (2024)  
              • Lancet regional health - Europe
               Fischer TK, Johannesen CK, Berginc N, Bailly JL, Benschop K, Harvala H


            •   (2023)  
                 Knight C, Andreani J, Garrett N, Winter M, Golubchik T, Breuer J, Reynolds C, Brailsford SR, Harvala H, Simmonds P


              • Accelerated waning of the humoral response to COVID-19 vaccines in obesity  (2023)  
                   van der Klaauw AA, Horner EC, Pereyra-Gerber P, Agrawal U, Foster WS, Spencer S, Vergese B, Smith M, Henning E, Ramsay ID, Smith JA, Guillaume SM, Sharpe HJ, Hay IM, Thompson S, Innocentin S, Booth LH, Robertson C, McCowan C, Kerr S, Mulroney TE, O'Reilly MJ, Gurugama TP, Gurugama LP, Rust MA, Ferreira A, Ebrahimi S, Ceron-Gutierrez L, Scotucci J, Kronsteiner B, Dunachie SJ, Klenerman P, PITCH Consortium, Park AJ, Rubino F, Lamikanra AA, Stark H, Kingston N, Estcourt L, Harvala H, Roberts DJ, Doffinger R, Linterman MA, Matheson NJ, Sheikh A, Farooqi IS, Thaventhiran JED



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