A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Design and implementation of blood donor sample bioarchives to enhance preparedness for emerging and pandemic pathogens in England
Tekijät: Secret, Shannah; Simmonds, Peter; Olver, Janie; Rajendra, Piya; Hart, Eilish; Lamikanra, Abigail A; Tsang, Hoi Pat; Garrett, Niel; Reynolds, Claire; Roberts, David J; Brailsford, Susan R; Semper, Amanda; Harvala, Heli
Kustantaja: European Centre for Disease Control and Prevention (ECDC)
Julkaisuvuosi: 2025
Lehti:Eurosurveillance
Vuosikerta: 30
Numero: 44
ISSN: 1025-496X
eISSN: 1560-7917
DOI: https://doi.org/10.2807/1560-7917.ES.2025.30.44.2500163
Verkko-osoite: https://doi.org/10.2807/1560-7917.es.2025.30.44.2500163
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/505284359
New and emerging infections with blood-borne pathogens pose an ongoing threat to the safety of blood transfusions and transplants. Bioarchives of stored blood donor samples represent a valuable pathogen screening resource for both ensuring safety of blood transfusions and for wider public health infectious disease surveillance. Large scale testing of donors enables early detection of pathogen spread and extent of population exposure. We have implemented two complementary systems for the bioarchiving of blood donor samples in England for these purposes. The CODONET bioarchive collects samples from geographically targeted regions of potential pathogen emergence. Consenting donors provide detailed information to allow for risk assessment and, importantly, to distinguish imported from autochthonously acquired infection. Separately, the blood donor surveillance archive (BDSA) stores 100 or 200 pools of 24 randomly selected, fully anonymised donation samples from donors in England every 2 weeks, allowing large-scale continuous sampling. This enables rapid evaluation of the presence of blood-borne pathogens in donor populations and a large-scale epidemiological tool to detect pathogen emergence in real-time. Combined, these bioarchives allow for proactive assessment of donation transmission risk, and as targeted population-wide archives, contribute to public health surveillance of emerging pathogens and pandemic spread.
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This work was supported by the National Institutes for Health and Care Research [grant number NIHR203338]. The funding body had no role in the study's design, data collection, analysis, or manuscript writing. JO, EH and AS are supported by the UK Health Security Agency. EH and AS are affiliated with the National Institute for Health & Social Care Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections (grant NINR200907) at the University of Liverpool in partnership with the UK Health Security Agency (UKHSA), and in collaboration with the Liverpool School of Tropical Medicine and The University of Oxford. EH studies at the University of Liverpool and is based at UKHSA, Porton Down. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health or the UK Health Security Agency.
