Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Comparison of Gd-DTPA-induced signal enhancements in rat brain c6 glioma among different pulse sequences in 3-tesla magnetic resonance imaging (2008)
- Acta Radiologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Heart and brain circulation and CO2 in healthy men (2008)
- Acta Physiologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate (2008)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Three-dimensional SPECT reconstruction with transmission-dependent scatter correction (2008)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - 3D-OSEM reconstruction from truncated data in pinhole SPECT (2007)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Accelerated 3D-OSEM image reconstruction using a Beowulf PC cluster for pinhole SPECT (2007)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats (2007)
- Stroke
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method (2007)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Comparison of multi-ray and point-spread function based resolution recovery methods in pinhole SPECT reconstruction (2006)
- Nuclear Medicine Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable O-15-O-2 (2006)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction (2006)
- Hypertension
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR+ positron emission scanners (2006)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose I-123-iodoamphetamine and single photon emission computed tomography (2006)
- NeuroImage
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - System design and development of a pinhole SPECT system for quantitative functional imaging of small animals (2006)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia (2006)
- Brain
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging (2006)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease (2006)
- Annals of Neurology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method (2005)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Parametric imaging of myocardial blood flow with O-15-water and PET using the basis function method (2005)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Rapid quantitative measurement of CMRO2 and GBF by dual administration of O-15-labeled oxygen and water during a single PET scan - a validation study and error analysis in anesthetized monkeys (2005)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )