A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Comparison of Gd-DTPA-induced signal enhancements in rat brain c6 glioma among different pulse sequences in 3-tesla magnetic resonance imaging
Tekijät: Sato H, Enmi J, Teramoto N, Hayashi T, Yamamoto A, Tsuji T, Naito H, Iida H
Kustantaja: TAYLOR & FRANCIS LTD
Julkaisuvuosi: 2008
Journal: Acta Radiologica
Tietokannassa oleva lehden nimi: ACTA RADIOLOGICA
Lehden akronyymi: ACTA RADIOL
Vuosikerta: 49
Numero: 2
Aloitussivu: 172
Lopetussivu: 179
Sivujen määrä: 8
ISSN: 0284-1851
DOI: https://doi.org/10.1080/02841850701630326
Tiivistelmä
Background: T1-shortening contrast media are routinely used in magnetic resonance (MR) examinations for the diagnosis of brain tumors. Although some studies show a benefit of 3 Tesla (T) compared to 1.5T in delineation of brain tumors using contrast media, it is unclear which pulse sequences are optimal.Purpose: To compare gadopentetate dimeglumine (Gd-DTPA)-induced signal enhancements in rat brain C6 glioma in the thalamus region among different pulse sequences in 3T MR imaging.Material and Methods: Five rats with a surgically implanted C6 glioma in their thalamus were examined. T1-weighted brain images of the five rats were acquired before and after Gd-DTPA administration (0.1mmol/kg) using three clinically available pulse sequences (spin echo [SE], fast SE [FSE], fast spoiled gradient echo [FSPGR]) at 3T. Signal enhancement in the glioma (ET) was calculated as the signal intensity after Gd-DTPA administration scaled by that before administration. Pulse sequences were compared using the Tukey-Kramer test.Results: ET was 1.120.05 for FSE, 1.260.11 for FSPGR, and 1.200.11 for SE. FSPGR showed significantly higher signal enhancement than FSE and comparable enhancement to SE.Conclusion: FSPGR is superior to FSE and comparable to SE in its ability to delineate rat brain C6 glioma in the thalamus region.
Background: T1-shortening contrast media are routinely used in magnetic resonance (MR) examinations for the diagnosis of brain tumors. Although some studies show a benefit of 3 Tesla (T) compared to 1.5T in delineation of brain tumors using contrast media, it is unclear which pulse sequences are optimal.Purpose: To compare gadopentetate dimeglumine (Gd-DTPA)-induced signal enhancements in rat brain C6 glioma in the thalamus region among different pulse sequences in 3T MR imaging.Material and Methods: Five rats with a surgically implanted C6 glioma in their thalamus were examined. T1-weighted brain images of the five rats were acquired before and after Gd-DTPA administration (0.1mmol/kg) using three clinically available pulse sequences (spin echo [SE], fast SE [FSE], fast spoiled gradient echo [FSPGR]) at 3T. Signal enhancement in the glioma (ET) was calculated as the signal intensity after Gd-DTPA administration scaled by that before administration. Pulse sequences were compared using the Tukey-Kramer test.Results: ET was 1.120.05 for FSE, 1.260.11 for FSPGR, and 1.200.11 for SE. FSPGR showed significantly higher signal enhancement than FSE and comparable enhancement to SE.Conclusion: FSPGR is superior to FSE and comparable to SE in its ability to delineate rat brain C6 glioma in the thalamus region.
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