Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Design and experimental validation of a quantitative myocardial Tl-201 SPECT system (1999)
- IEEE Transactions on Nuclear Science
- Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance - Studies with PET and 14(R, S)-[F-18]fluoro-6-thia-heptadecanoic acid (1999)
- Diabetes
- Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism (1999)
- Journal of Nuclear Medicine
- Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy (1999)
- Circulation
- Synthesis and autoradiographic localization of muscarinic cholinergic antagonist (+)N-[C-11]methyl-3-piperidyl benzilate as a potent radioligand for positron emission tomography (1999)
- Applied Radiation and Isotopes
- Coronary flow reserve is reduced in young men with IDDM (1998)
- Diabetes
- Early impairment of coronary flow reserve in young men with borderline hypertension (1998)
- Journal of the American College of Cardiology
- Effects of scatter correction on regional distribution of cerebral blood flow using SPECT. (1998)
- Journal of Nuclear Medicine
- Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle (1998)
- Journal of Hypertension
- Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a Dual-PET system (1998)
- Journal of Nuclear Medicine
- Optimized acquisition time and image sampling for dynamic SPECT of Tl-201 (1998)
- IEEE Transactions on Medical Imaging
- Quantitative assessment of regional myocardial blood flow with thallium-201 and SPECT (1998)
- Journal of Nuclear Cardiology
- Effects of insulin on blood flow and volume in skeletal muscle of patients with IDDM - Studies using [O-15]H2O, [O-15]CO, and positron emission tomography (1997)
- Diabetes
- Influence of cardiovascular risk status on coronary flow reserve in healthy young men (1997)
- American Journal of Cardiology
- In vivo low density lipoprotein oxidation relates to coronary reactivity in young men (1997)
- Journal of the American College of Cardiology
- Monte Carlo evaluation of accuracy and noise properties of two scatter correction methods for Tl-201 cardiac SPECT (1997)
- IEEE Transactions on Nuclear Science
- Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET (1997)
- Journal of Nuclear Medicine
- Regional cerebral blood flow measurement with iodine-123-IMP autoradiography: Normal values, reproducibility and sensitivity to hypoperfusion (1997)
- Journal of Nuclear Medicine
- A multicenter validation of regional cerebral blood flow quantitation using [I-123]iodoamphetamine and single photon emission computed tomography (1996)
- Journal of Cerebral Blood Flow and Metabolism
- Coronary flow reserve is impaired in young men with familial hypercholesterolemia (1996)
- Journal of the American College of Cardiology