Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle

: Laine H, Knuuti MJ, Ruotsalainen U, Raitakari M, Iida H, Kapanen J, Kirvela O, Haaparanta M, Yki-Jarvinen H, Nuutila P

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 1998

: Journal of Hypertension

: JOURNAL OF HYPERTENSION

: J HYPERTENS

: 16

: 2

: 211

: 219

: 9

: 0263-6352

DOI: https://doi.org/10.1097/00004872-199816020-00012

Objective To determine whether insulin-stimulated blood flow in patients with mild essential hypertension is altered.Subjects Eleven untreated mildly hypertensive patients [aged 35 +/- 2 years, body mass index 25.1 +/- 0.4 kg/m(2), mean arterial pressure 110 +/- 2 mmHg (means +/- SEM) and 10 matched normotensive subjects (mean arterial pressure 94 +/- 3 mmHg).Methods Blood flow was quantitated directly in skeletal muscle both basally and during supraphysiologic hyperinsulinemia (serum insulin congruent to 450 mU/I) using radiowater ([O-15]H2O) and positron emission tomography. Whole-body and femoral muscle glucose uptakes were determined using the euglycemic insulin clamp technique, [F-18]-2-fluoro-2-deoxy-D-glucose and positron emission tomography.Results Rates of whole-body and femoral muscle glucose uptake were significantly lower in the hypertensive than in the normotensive group. insulin increased muscle blood flow by 91% in the normotensive group, but only by 33% in the hypertensive group.Conclusions The ability of insulin to stimulate blood flow in patients with mild essential hypertension is impaired. (C) 1998 Rapid Science Ltd.