Partho Sen
 

Systems Medicine

partho.sen@utu.fi




https://orcid.org/0000-0003-0475-2763

ResearchGate

My personal website

Google Scholar profile



Machine Learning, Biomarker Discovery, R (Programming Language), Python (Programming Language), MATLAB, Snakemake, High Performance Computing (HPC), Computational Biology, Bioinformatics, Mathematical Modeling,
Statistical Modeling, Statistical Data Analysis, Metabolomics, Single Cell Sequencing, Functional Genomics, Transcriptomics, Metagenomics, NGS, Proteomics, Human Genetics.



I've a 13-year background in computational biology and bioinformatics. My professional / research journey has been marked to unravel the intricacies of molecular signatures and processes in humans and microbes.

Currently specializing in precision and systems medicine, my focus centers on multiple myeloma and other cancer types. By utilization of multiomics (genomics, transcriptomics, proteomics and metabolomics) and clinical datasets, I tend to delineate cellular signatures and pathways associated with cancer, contributing to the biomarker discovery, and thereby attributing towards the cancer treatment.

My prior research has delved into diverse health conditions, including Diabetes (Type 1 & 2), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, and Cardiovascular disease (Atherosclerosis). The overarching objective of my work is to identify molecular markers that serve as key insights into disease mechanisms and underlying pathways. Thereby, aim to formulate innovative drugs, inhibitors, and therapeutic strategies.

In addition to my proficiency in mathematical, statistical modeling and data science, I am an accomplished computer programmer; well-versed in machine learning. My passion lies in harnessing large datasets to design tools and methods that address contemporary challenges in healthcare, as well as cell and tissue biology.

I am confident that with my expertise, we can achieve significant breakthroughs in understanding and treating diseases that have hitherto posed significant challenges.



  
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  • Dysregulation of Microbiota in Patients With First-Episode Psychosis Is Associated With Symptom Severity and Treatment Response  (2024)  
    • Biological PsychiatryCell Reports
     Sen Partho, Prandovszky Emese, Honkanen Jarno K., Chen Ou, Yolken Robert, Suvisaari Jaana


  • Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity  (2024)  
    • Environment InternationalMetabolomics
     Sen Partho, Fan Yong, Schlezinger Jennifer J., Ehrlich Stanislav D., Webster Thomas F., Hyötyläinen Tuulia, Pedersen Oluf, Orešič Matej


  • Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis  (2024)  
    • Cell Reports Medicine
     Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia


  • 1‐deoxyceramides – key players in lipotoxicity and progression to type 2 diabetes?2024
    • Proceedings of the National Academy of Sciences of the United States of America
     Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta


  • Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children  (2023)  
    • Frontiers in EndocrinologySchizophrenia Bulletin
     Lamichhane Santosh, Sen Partho, Dickens Alex M, Kråkström Matilda, Ilonen Jorma, Lempainen Johanna, Hyöty Heikki, Lahesmaa Riitta, Veijola Riitta, Toppari Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej


  • Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species  (2023)  
    • Computational and Structural Biotechnology JournalScientific Reports
     Mathema Vivek Bhakta, Sen Partho, Lamichhane Santosh, Orešič Matej, Khoomrung Sakda


  • Use of big data from health insurance for assessment of cardiovascular outcomes  (2023)  
    • Frontiers in Artificial Intelligence
     Krefting Johannes, Sen Partho, David-Rus Diana, Güldener Ulrich, Hawe Johann S, Cassese Salvatore, von Scheidt Moritz, Schunkert Heribert


  • Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetesDysregulated lipid metabolism precedes onset of psychosis2022
    • Cell Reports MedicineBiological Psychiatry
     Lamichhane Santosh, Sen Partho, Dickens Alex M., Alves Marina Amaral, Härkönen Taina, Honkanen Jarno, Vatanen Tommi, Xavier Ramnik J., Hyötyläinen Tuulia, Knip Mikael, Oresic Matej


  •   (2022)  
    • Journal of HepatologyMetabolites
     Sen Partho, Qadri Sami, Luukkonen Panu K, Ragnarsdottir Oddny, McGlincheyAidan , Jäntti Sirkku, Juuti Anne, Arola Johanna, Schlezinger Jennifer J, Webster Thomas F, Orešič Matej, Yki-Järvinen Hannele, Hyötyläinen Tuulia


  •   (2022)  
    • JHEP Reports
     Katherine Johnson, Peter J Leary, Olivier Govaere, Matthew J Barter, Sarah H Charlton, Simon J Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M Julia Brosnan, Jeremy F Cobbold, Mattias Ekstedt, Guruprasad P Aithal, Karine Clément, Jörn M Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M Anstee, Ann K Daly, on behalf of the
    LITMUS Consortium Investigators,

    James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss


  • Metabolomic and proteomic profiling in bipolar disorder patients revealed potential molecular signatures related to hemostasis  (2022)  
       Caracho Ribeiro Henrique, Sen Partho, Dickens Alex, Santa Cruz Elisa Castañeda, Orešič Matej, Sussulini Alessandra


    • Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease  (2022)  
      • iScience
       Sen Partho, Govaere Olivier, Sinioja Tim, McGlinchey Aidan, Geng Dawei, Ratziu Vlad, Bugianesi Elisabetta, Schattenberg Jörn M, Vidal-Puig Antonio, Allison Michael, Cockell Simon, Daly Ann K, Hyötyläinen Tuulia, Anstee Quentin M, Orešič Matej


    •   (2021)  
      • Acta Physiologica
       Sen Partho, Hyötyläinen Tuulia, Orešič Matej


    • Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis  (2021)  
         Lamichhane Santosh, Dickens Alex M, Sen Partho, Laurikainen Heikki, Borgan Faith, Suvisaari Jaana, Hyötyläinen Tuulia, Howes Oliver, Hietala Jarmo, Orešič Matej


      •   (2021)  
           Petersen Anders Ø, Julienne Hanna, Hyötyläinen Tuulia, Sen Partho, Fan Yong, Krogh Pedersen Helle, Jäntti Sirkku, Hansen Tue H., Nielsen Trine, Jørgensen Torben, Hansen Torben, Myers Pernille Neve, Nielsen H. Bjørn, Ehrlich S. Dusko, Orešič Matej, Pedersen Oluf


        •   (2021)  
          • Briefings in Bioinformatics
           Partho Sen, Santosh Lamichhane, Vivek B Mathema, Aidan McGlinchey, Alex M Dickens, Sakda Khoomrung, Matej Orešič


        •   (2021)  
             Alex M Dickens, Partho Sen, Matthew J Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rössler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyötyläinen, Matej Orešič, Philip McGuire


          • Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations  (2021)  
               Lamichhane Santosh, Sen Partho, Amaral Alves Marina, Ribeiro Henrique C, Raunioniemi Peppi, Hyötyläinen Tuulia, Orešič Matej


            • Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways  (2021)  
                 Partho Sen, Syed Bilal Ahmad Andrabi, Tanja Buchacher, Mohd Moin Khan, Ubaid Ullah Kalim, Tuomas Mikael Lindeman, Marina Amaral Alves, Victoria Hinkkanen, Esko Kemppainen, Alex M Dickens, Omid Rasool, Tuulia Hyötyläinen, Riitta Lahesmaa, Matej Orešič


              • Systems biology approaches to study lipidomes in health and disease  (2021)  
                • Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
                 Marina Amaral Alves, Santosh Lamichhane, Alex Dickens, Aidan McGlinchey, Henrique C Ribeiro, Partho Sen, Fang Wei, Tuulia Hyötyläinen, Matej Orešič



              Last updated on 2024-22-11 at 17:44