Partho Sen
Machine Learning, Biomarker Discovery, R (Programming Language), Python (Programming Language), MATLAB, Snakemake, High Performance Computing (HPC), Computational Biology, Bioinformatics, Mathematical Modeling,
Statistical Modeling, Statistical Data Analysis, Metabolomics, Single Cell Sequencing, Functional Genomics, Transcriptomics, Metagenomics, NGS, Proteomics, Human Genetics.
I've a 13-year background in computational biology and bioinformatics. My professional / research journey has been marked to unravel the intricacies of molecular signatures and processes in humans and microbes.
Currently specializing in precision and systems medicine, my focus centers on multiple myeloma and other cancer types. By utilization of multiomics (genomics, transcriptomics, proteomics and metabolomics) and clinical datasets, I tend to delineate cellular signatures and pathways associated with cancer, contributing to the biomarker discovery, and thereby attributing towards the cancer treatment.
My prior research has delved into diverse health conditions, including Diabetes (Type 1 & 2), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, and Cardiovascular disease (Atherosclerosis). The overarching objective of my work is to identify molecular markers that serve as key insights into disease mechanisms and underlying pathways. Thereby, aim to formulate innovative drugs, inhibitors, and therapeutic strategies.
In addition to my proficiency in mathematical, statistical modeling and data science, I am an accomplished computer programmer; well-versed in machine learning. My passion lies in harnessing large datasets to design tools and methods that address contemporary challenges in healthcare, as well as cell and tissue biology.
I am confident that with my expertise, we can achieve significant breakthroughs in understanding and treating diseases that have hitherto posed significant challenges.
- Dysregulation of Microbiota in Patients With First-Episode Psychosis Is Associated With Symptom Severity and Treatment Response (2024)
- Biological Psychiatry
- Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity (2024)
- Environment International
- Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)
- Cell Reports Medicine
- Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024)
- Proceedings of the National Academy of Sciences of the United States of America
- Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
- Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine (2023)
- Computational and Structural Biotechnology Journal
- Use of big data from health insurance for assessment of cardiovascular outcomes (2023)
- Frontiers in Artificial Intelligence
- Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes (2022)
- Cell Reports Medicine
- Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease (2022)
- Journal of Hepatology
- Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance (2022)
- JHEP Reports
LITMUS Consortium Investigators,
James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss - Metabolomic and proteomic profiling in bipolar disorder patients revealed potential molecular signatures related to hemostasis (2022)
- Metabolomics
- Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease (2022)
- iScience
- 1‐deoxyceramides – key players in lipotoxicity and progression to type 2 diabetes? (2021)
- Acta Physiologica
- Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis (2021)
- Schizophrenia Bulletin
- Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species (2021)
- Scientific Reports
- Deep learning meets metabolomics: a methodological perspective (2021)
- Briefings in Bioinformatics
- Dysregulated lipid metabolism precedes onset of psychosis (2021)
- Biological Psychiatry
- Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations (2021)
- Metabolites
- Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways (2021)
- Cell Reports
- Systems biology approaches to study lipidomes in health and disease (2021)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids