Santosh Lamichhane
Academy Research fellow
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santosh.lamichhane@utu.fi
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Lipidomics/Metabolomics
Gut microbial metabolism
Multivariate data analysis
Reverse Metabolomics
Molecular networking
Santosh Lamichhane is a Research Council of Finland Academy Research Fellow. He holds the title of Docent, equivalent to Associate Professor, in Metabolomics at the Department of Life Technologies, University of Turku.
As part of his research fellowship, Lamichhane will investigate the relationship between gut microbiota, lipids, and their clinical effects in early childhood.
Lamichhane was a Visiting Researcher at The Dorrestein Lab, University of California, San Diego, where he gained expertise in reverse and repository-scale metabolomics to better understand microbial chemistry and its influence on human metabolism.
Lamichhane's research interest lies in the interface of human health, diet and gut microbial activity. He wants to connect these dots (health, diet, microbes) by profiling small molecules (termed as metabolites), which circulates in our body. To be very specific Lamichhanes core interest are reflected by following keywords:
- Metabolomics-Metabolites-Small molecules
- Human Nutrition and health
- Pre and Probiotics / Gut Microbiome
- Human intervention study
Relating to Lamichhane's experience, he has spent approximately a decade profiling small molecules in relation to human heath and (or) gut metabolome. He is open to collaborations relating to gut, health, metabolites and microbiome.
Metabolomics lecture in Systems biology (SYS21012), Modern biotechnologies and bioinformatics course (BIOT1524), Bioanalytical Techniques (CHEMI6429) at University of Turku.
- A guide to reverse metabolomics—a framework for big data discovery strategy (2025) Charron-Lamoureux, Vincent; Mannochio-Russo, Helena; Lamichhane, Santosh; Xing, Shipei; Patan, Abubaker; Gomes, Paulo Wender Portal; Rajkumar, Prajit; Deleray, Victoria; Caraballo-Rodriguez, Andres Mauricio; Chua, Kee Voon; Lee, Lye Siang; Liu, Zhao; Ching, Jianhong; Wang, Mingxun; Dorrestein, Pieter C.
- Intra- and inter-individual variation of the human lipidome (2025)
- Trends in Analytical Chemistry
Anh, Nguyen Hoang; Beyene, Habtamu B.; Mocciaro, Gabriele; Hahnefeld, Lisa; Lamichhane, Santosh; Fabritius, Mikael; Avela, Henri; Wang, Yuqin; Dickens, Alex M.; Gurke, Robert; Yang, Baoru; Griffiths, William J.; Hyötyläinen, Tuulia; Meikle, Peter J.; Orešič, Matej
- The microbiome diversifies long-to short-chain fatty acid-derived N-acyl lipids (2025) Mannochio-Russo, Helena; Charron-Lamoureux, Vincent; van Faassen, Martijn; Lamichhane, Santosh; Nunes, Wilhan D. Goncalves; Deleray, Victoria; Ayala, Adriana, V; Tanaka, Yuichiro; Patan, Abubaker; Vittali, Kyle; Rajkumar, Prajit; El Abiead, Yasin; Zhao, Haoqi Nina; Gomes, Paulo Wender Portal; Mohanty, Ipsita; Lee, Carlynda; Sund, Aidan; Sharma, Meera; Liu, Yuanhao; Pattynama, David; Walker, Gregory T.; Norton, Grant J.; Khatib, Lora; Andalibi, Mohammadsobhan S.; Wang, Crystal X.; Ellis, Ronald J.; Moore, David J.; Iudicello, Jennifer E.; Franklin Jr, Donald; Letendre, Scott; Chin, Loryn; Walker, Corinn; Renwick, Simone; Zemlin, Jasmine; Meehan, Michael J.; Song, Xinyang; Kasper, Dennis; Burcham, Zachary; Kim, Jane J.; Kadakia, Sejal; Raffatellu, Manuela; Bode, Lars; Chu, Hiutung; Zengler, Karsten; Wang, Mingxun; Siegel, Dionicio; Knight, Rob; Dorrestein, Pieter C.
- Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization (2024) Isokääntä Heidi, Pinto da Silva Lucas, Karu Naama, Kallonen Teemu, Aatsinki Anna-Katariina, Hankemeier Thomas, Schimmel Leyla, Diaz Edgar, Hyötyläinen Tuulia, Dorrestein Pieter C., Knight Rob, Orešič Matej, Kaddurah-Daouk Rima, Dickens Alex M., Lamichhane Santosh
- IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis (2024) Zhang P., Liu J., Lee A., Tsaur I., Ohira M., Duong V., Vo N., Watari K., Su H., Kim J.Y., Gu L., Zhu M., Shalapour S., Hosseini M., Bandyopadhyay G., Zeng S., Llorente C., Zhao H.N., Lamichhane S., Mohan S., Dorrestein P.C., Olefsky J.M., Schnabl B., Soroosh P., Karin M.
- Infant gut microbiota and negative and fear reactivity (2024)
- Development and Psychopathology
Huovinen Venla, Aatsinki Anna-Katariina, Kataja Eeva-Leena, Munukka Eveliina, Keskitalo Anniina, Lamichhane Santosh, Raunioniemi Peppi, Bridgett David J., Lahti Leo, O’Mahony Siobhain M., Dickens Alex, Korja Riikka, Karlsson Hasse, Nolvi Saara, Karlsson Linnea
- Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors (2024) Cruz, Abraham Kuri; Alves, Marina Amaral; Andresson, Thorkell; Bayless, Amanda L.; Bloodsworth, Kent J.; Bowden, John A.; Bullock, Kevin; Burnet, Meagan C.; Carnevale Neto, Fausto; Choy, Angelina; Clish, Clary B.; Couvillion, Sneha P.; Cumeras, Raquel; Dailey, Lucas; Dallmann, Guido; Davis, W. Clay; Deik, Amy A.; Dickens, Alex M.; Djukovic, Danijel; Dorrestein, Pieter C.; Eder, Josie G.; Fiehn, Oliver; Flores, Roberto; Gika, Helen; Hagiwara, Kehau A.; Pham, Tuan Hai; Harynuk, James J.; Aristizabal-Henao, Juan J.; Hoyt, David W.; Jean-Francois, Focant; Krakstroem, Matilda; Kumar, Amit; Kyle, Jennifer E.; Lamichhane, Santosh; Li, Yuan; Nam, Seo Lin; Mandal, Rupasri; de la Mata, A. Paulina; Meehan, Michael J.; Meikopoulos, Thomas; Metz, Thomas O.; Mouskeftara, Thomai; Munoz, Nathalie; Gowda, G. A. Nagana; Orešic, Matej; Panitchpakdi, Morgan; Pierre-Hugues, Stefanuto; Raftery, Daniel; Rushing, Blake; Schock, Tracey; Seifried, Harold; Servetas, Stephanie; Shen, Tong; Sumner, Susan; Carrillo, Kieran S. Tarazona; Thibaut, Dejong; Trejo, Jesse B.; Van Meulebroek, Lieven; Vanhaecke, Lynn; Virgiliou, Christina; Weldon, Kelly C.; Wishart, David S.; Zhang, Lu; Zheng, Jiamin; Da Silva, Sandra
- Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk (2024) Bhosale, Santosh D.; Moulder, Robert; Suomi, Tomi; Ruohtula, Terhi; Honkanen, Jarno; Virtanen, Suvi M.; Ilonen, Jorma; Elo, Laura L.; Knip, Mikael; Lahesmaa, Riitta
- Changes in lipids and inflammation in adults with super-refractory status epilepticus on a ketogenic diet (2023)
- Frontiers in Molecular Biosciences
Dickens Alex M, Johnson Tory P, Lamichhane Santosh, Kumar Anupama, Pardo Carlos A, Gutierrez Erie G, Haughey Norman, Cervenka Mackenzie C
- Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
Lamichhane Santosh, Sen Partho, Dickens Alex M, Kråkström Matilda, Ilonen Jorma, Lempainen Johanna, Hyöty Heikki, Lahesmaa Riitta, Veijola Riitta, Toppari Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej
- Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study (2023)
- International Journal of Molecular Sciences
Monfort-Pires Milena, Lamichhane Santosh, Alonso Cristina, Egelandsdal Bjørg, Oresic Matej, Jordahl Vilde Overrein, Skjolsvold Oda, Perez-Ruiz Irantzu, Blanco Maria Encarnación, Skeie Siv, Martins Catia, Haug Anna
- Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine (2023)
- Computational and Structural Biotechnology Journal
Mathema Vivek Bhakta, Sen Partho, Lamichhane Santosh, Orešič Matej, Khoomrung Sakda
- Dynamics of the Lipidome in a Colon Simulator (2023) Kråkström Matilda, Dickens Alex M, Amaral Alves Marina, Forssten Sofia D, Ouwehand Arthur C, Hyötyläinen Tuulia, Orešič Matej, Lamichhane Santosh
- Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads (2023)
- Environment International
Lamichhane Santosh, Härkönen Taina, Vatanen Tommi, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej
- Recent advances towards mass spectrometry-based clinical lipidomics (2023)
- Current Opinion in Chemical Biology
Salihovic Samira, Lamichane Santosh, Hyötyläinen Tuulia, Orešič Matej
- Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes (2022) Lamichhane Santosh, Sen Partho, Dickens Alex M., Alves Marina Amaral, Härkönen Taina, Honkanen Jarno, Vatanen Tommi, Xavier Ramnik J., Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
- Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life (2022) Lamichhane Santosh, Siljander Heli, Salonen Marja, Ruohtula Terhi, Virtanen Suvi M., Ilonen Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej
- Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis (2021) Lamichhane Santosh, Dickens Alex M, Sen Partho, Laurikainen Heikki, Borgan Faith, Suvisaari Jaana, Hyötyläinen Tuulia, Howes Oliver, Hietala Jarmo, Orešič Matej
- Deep learning meets metabolomics: a methodological perspective (2021)
- Briefings in Bioinformatics
Partho Sen, Santosh Lamichhane, Vivek B Mathema, Aidan McGlinchey, Alex M Dickens, Sakda Khoomrung, Matej Orešič
- Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk (2021)
- Environment International
Lamichhane Santosh, Siljander Heli, Duberg Daniel, Honkanen Jarno, Virtanen Suvi M., Orešič Matej, Knip Mikael, Hyötyläinen Tuulia