Santosh Lamichhane
Academy Research fellow, Adj Prof (Docent), Group Leader,Infection and Immunity Unit at the Institute of Biomedicine.
Areas of expertise
Lipidomics/Metabolomics-
Gut microbial metabolism-
Multivariate data analysis
Reverse Metabolomics- Molecular networking
Research community or research topic
Lamichhane Group- Gut Microbiomics-The focus of our group is to explore microbial derived small molecules in the gut and their influence on human health.
Biography
Santosh Lamichhane is the Principal Investigator in the Infection and Immunity Unit at the Institute of Biomedicine. He is a Research Council of Finland Academy Research Fellow and holds the title of Docent (equivalent to Associate Professor) in Metabolomics at the Department of Life Technologies, University of Turku. As part of his research fellowship, Dr. Lamichhane investigates the relationship between gut microbiota, lipids, and their clinical effects in early childhood.
Lamichhane was a Visiting Researcher at The Dorrestein Lab, University of California, San Diego, where he gained expertise in reverse and repository-scale metabolomics to better understand microbial chemistry and its influence on human metabolism.
Research
Lamichhane's research interest lies in the interface of human health, diet and gut microbial activity. He heads a research group (Gut Microbiomics) at Intitute of Biomedicine, Faculty of Medicine. https://sites.utu.fi/gutmicrobiomics/
The focus of his group is to explore microbial derived small molecules in the gut and their influence on human health. By integrating advanced laboratory techniques such as metabolomics, gut organoids, and microbial cultures with computational analysis, we investigate the chemical interactions between gut microbes and their impact on the host.
Teaching
Metabolomics lecture in Systems biology (SYS21012), Modern biotechnologies and bioinformatics course (BIOT1524), Bioanalytical Techniques (CHEMI6429) at University of Turku.
Publications
- Association between infant and toddler gut microbiota composition and later executive functioning (2026)
- Development and Psychopathology
Huovinen, Venla; Aatsinki, Anna-Katariina; Eskola, Eeva; Benedetti, Giulio; Isokääntä, Heidi; Nordenswan, Elisabeth; Munukka, Eveliina; Lamichhane, Santosh; Yada, Akie; O’Mahony, Siobhain M.; Dickens, Alex; Lahti, Leo; Karlsson, Hasse; Korja, Riikka; Nolvi, Saara; Karlsson, Linnea
(A1 Refereed original research article in a scientific journal)
- Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity (2026) Lamichhane, Santosh; Dickens, Alex M.; Buchacher, Tanja; Lou, Tianai; Charron-Lamoureux, Vincent; Kattelus, Roosa; Karmacharya, Pragya; Pinto da Silva, Lucas; Kråkström, Matilda; Rasool, Omid; Sen, Partho; Walker, Corinn; Patan, Abubaker; Gentry, Emily C.; Zuffa, Simone; Arzoomand, Aron; Lakshmikanth, Tadepally; Mikeš, Jaromir; Mebrahtu, Aman; Vatanen, Tommi; Raffatellu, Manuela; Zengler, Karsten; Hyötyläinen, Tuulia; Xavier, Ramnik J.; Brodin, Petter; Lahesmaa, Riitta; Dorrestein, Pieter C.; Knip, Mikael; Orešič, Matej
(A1 Refereed original research article in a scientific journal)
- Pre- and postnatal maternal psychological distress and the metabolomic profile of human milk (2026) Ryan, Niamh; Sundekilde, Ulrik Kramer; Dickens, Alex M.; Kalant, Henna-Maria; Leahy-Warren, Patricia; Philpott, Lloyd; Mulcahy, Helen; Lamichhane, Santosh; Isokääntä, Heidi; Perasto, Laura; Tarro, Saija; Karlsson, Hasse; Karlsson, Linnea; O’Mahony, Siobhain M.; Aatsinki, Anna-Katariina
(A1 Refereed original research article in a scientific journal)
- Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring (2026)
- Environment International
Lamichhane, Santosh; Salihovic, Samira; Sinioja, Tim; Virtanen, Suvi M.; Vatanen, Tommi; Orešič, Matej; Knip, Mikael; Hyötyläinen, Tuulia
(A1 Refereed original research article in a scientific journal)
- A guide to reverse metabolomics—a framework for big data discovery strategy (2025) Charron-Lamoureux, Vincent; Mannochio-Russo, Helena; Lamichhane, Santosh; Xing, Shipei; Patan, Abubaker; Gomes, Paulo Wender Portal; Rajkumar, Prajit; Deleray, Victoria; Caraballo-Rodriguez, Andres Mauricio; Chua, Kee Voon; Lee, Lye Siang; Liu, Zhao; Ching, Jianhong; Wang, Mingxun; Dorrestein, Pieter C.
(A1 Refereed original research article in a scientific journal)
- A resource to empirically establish drug exposure records directly from untargeted metabolomics data (2025) Zhao, Haoqi Nina; Kvitne, Kine Eide; Brungs, Corinna; Mohan, Siddharth; Charron-Lamoureux, Vincent; Bittremieux, Wout; Tang, Runbang; Schmid, Robin; Lamichhane, Santosh; Xing, Shipei; El Abiead, Yasin; Andalibi, Mohammadsobhan S.; Mannochio-Russo, Helena; Ambre, Madison; Avalon, Nicole E.; Bryant, MacKenzie; Burnett, Lindsey A.; Caraballo-Rodríguez, Andrés Mauricio; Maya, Martin Casas; Chin, Loryn; Corominas, Lluís; Ellis, Ronald J.; Franklin, Donald; Girod, Sagan; Gomes, Paulo Wender, P.; Hansen, Lauren; Heaton, Robert K.; Iudicello, Jennifer E.; Jarmusch, Alan K.; Khatib, Lora; Letendre, Scott; Magyari, Sarolt; McDonald, Daniel; Mohanty, Ipsita; Cumsille, Andrés; Moore, David J.; Rajkumar, Prajit; Ross, Dylan H.; Sapre, Harshada; Shahneh, Mohammad Reza Zare; Gil-Solsona, Ruben; Thomas, Sydney P.; Tribelhorn, Caitlin; Tubb, Helena M.; Walker, Corinn; Wang, Crystal X.; Zemlin, Jasmine; Zuffa, Simone; Wishart, David S.; Gago-Ferrero, Pablo; Kaddurah-Daouk, Rima; Wang, Mingxun; Raffatellu, Manuela; Zengler, Karsten; Pluskal, Tomáš; Xu, Libin; Knight, Rob; Tsunoda, Shirley M.; Dorrestein, Pieter C.
(A1 Refereed original research article in a scientific journal)
- Dynamics of gut metabolome and microbiota maturation during early life (2025) Aatsinki, Anna-Katariina; Lamichhane, Santosh; Isokääntä, Heidi; Sen, Partho; Kråkström, Matilda; Amaral Alves, Marina; Keskitalo, Anniina; Munukka, Eveliina; Karlsson, Hasse; Perasto, Laura; Lukkarinen, Minna; Oresic, Matej; Kailanto, Henna-Maria; Karlsson, Linnea; Lahti, Leo; Dickens, Alex M.
(A1 Refereed original research article in a scientific journal)
- Intra- and inter-individual variation of the human lipidome (2025)
- Trends in Analytical Chemistry
Anh, Nguyen Hoang; Beyene, Habtamu B.; Mocciaro, Gabriele; Hahnefeld, Lisa; Lamichhane, Santosh; Fabritius, Mikael; Avela, Henri; Wang, Yuqin; Dickens, Alex M.; Gurke, Robert; Yang, Baoru; Griffiths, William J.; Hyötyläinen, Tuulia; Meikle, Peter J.; Orešič, Matej
(A2 Refereed review article in a scientific journal )
- The microbiome diversifies long-to short-chain fatty acid-derived N-acyl lipids (2025) Mannochio-Russo, Helena; Charron-Lamoureux, Vincent; van Faassen, Martijn; Lamichhane, Santosh; Nunes, Wilhan D. Goncalves; Deleray, Victoria; Ayala, Adriana, V; Tanaka, Yuichiro; Patan, Abubaker; Vittali, Kyle; Rajkumar, Prajit; El Abiead, Yasin; Zhao, Haoqi Nina; Gomes, Paulo Wender Portal; Mohanty, Ipsita; Lee, Carlynda; Sund, Aidan; Sharma, Meera; Liu, Yuanhao; Pattynama, David; Walker, Gregory T.; Norton, Grant J.; Khatib, Lora; Andalibi, Mohammadsobhan S.; Wang, Crystal X.; Ellis, Ronald J.; Moore, David J.; Iudicello, Jennifer E.; Franklin Jr, Donald; Letendre, Scott; Chin, Loryn; Walker, Corinn; Renwick, Simone; Zemlin, Jasmine; Meehan, Michael J.; Song, Xinyang; Kasper, Dennis; Burcham, Zachary; Kim, Jane J.; Kadakia, Sejal; Raffatellu, Manuela; Bode, Lars; Chu, Hiutung; Zengler, Karsten; Wang, Mingxun; Siegel, Dionicio; Knight, Rob; Dorrestein, Pieter C.
(A1 Refereed original research article in a scientific journal)
- Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization (2024) Isokääntä, Heidi; Pinto da Silva, Lucas; Karu, Naama; Kallonen, Teemu; Aatsinki, Anna-Katariina; Hankemeier, Thomas; Schimmel, Leyla; Diaz, Edgar; Hyötyläinen, Tuulia; Dorrestein, Pieter C.; Knight, Rob; Orešič, Matej; Kaddurah-Daouk, Rima; Dickens, Alex M.; Lamichhane, Santosh
(A1 Refereed original research article in a scientific journal)