Santosh Lamichhane
Academy Research fellow
santosh.lamichhane@utu.fi |
Lipidomics/Metabolomics- Gut microbial metabolism- Multivariate data analysis
Reverse Metabolomics- Molecular networking
Functional Gut Microbiomics-The focus of our group is to explore microbial derived small molecules in the gut and their influence on human health.
Santosh Lamichhane is a Research Council of Finland Academy Research Fellow. He holds the title of Docent, equivalent to Associate Professor, in Metabolomics at the Department of Life Technologies, University of Turku. As part of his research fellowship, Lamichhane will investigate the relationship between gut microbiota, lipids, and their clinical effects in early childhood.
Lamichhane was a Visiting Researcher at The Dorrestein Lab, University of California, San Diego, where he gained expertise in reverse and repository-scale metabolomics to better understand microbial chemistry and its influence on human metabolism.
Lamichhane's research interest lies in the interface of human health, diet and gut microbial activity. He heads a research group (Functional Gut Microbiomics) at Intitute of Biomedicine, Faculty of Medicine. The focus of his group is to explore microbial derived small molecules in the gut and their influence on human health. By integrating advanced laboratory techniques such as metabolomics, gut organoids, and microbial cultures with computational analysis, we investigate the chemical interactions between gut microbes and their impact on the host.
Metabolomics lecture in Systems biology (SYS21012), Modern biotechnologies and bioinformatics course (BIOT1524), Bioanalytical Techniques (CHEMI6429) at University of Turku.
- Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk (2021)
- Environment International
(A1 Refereed original research article in a scientific journal) - Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations (2021)
- Metabolites
(A2 Refereed review article in a scientific journal ) - Systems biology approaches to study lipidomes in health and disease (2021)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
(A2 Refereed review article in a scientific journal ) - Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes (2020)
- Environment International
(A1 Refereed original research article in a scientific journal) - Circulating metabolites in progression to islet autoimmunity and type 1 diabetes (2019)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)
- Biomolecules
(A1 Refereed original research article in a scientific journal) - Lipidomes in health and disease: Analytical strategies and considerations (2019)
- Trends in Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - The Role of Omic Technologies in the Study of the Human Gut Microbiome (2019) Reference Module in Food Science Partho Sen, Santosh Lamichhane, Alex M Dickens, Matej Orešič
(A3 Refereed book chapter or chapter in a compilation book) - A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes (2018)
- Scientific Data
(A1 Refereed original research article in a scientific journal) - An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives (2018) Comprehensive Analytical Chemistry Lamichhane S., Sen P., Dickens A., Hyötyläinen T., Orešič M.
(B2 Non-refereed book chapter or chapter in a compilation book) - Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP) (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe (2018)
- Methods
(A1 Refereed original research article in a scientific journal) - H-1 HR-MAS NMR-based metabolomics analysis for dry-fermented sausage characterization (2018)
- Food Chemistry
(A1 Refereed original research article in a scientific journal) - Metabolic Fate of C-13-Labeled Polydextrose and Impact on the Gut Microbiome: A Triple-Phase Study in a Colon Simulator (2018)
- Journal of Proteome Research
(A1 Refereed original research article in a scientific journal) - Optimizing sampling strategies for NMR-based metabolomics of human feces: pooled vs. unpooled analyses (2017)
- Analytical Methods
(A1 Refereed original research article in a scientific journal) - Gut microbial activity as influenced by fiber digestion: dynamic metabolomics in an in vitro colon simulator (2016)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies (2016)
- Frontiers in Oncology
(A1 Refereed original research article in a scientific journal) - Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes (2016)
- Cancer and Metabolism
(A1 Refereed original research article in a scientific journal) - High-resolution magic angle spinning studies of semi-hard Danbo (30+) cheese - impact of processing condition and relation to sensory perception (2015)
- Special Publication- Royal Society of Chemistry
(B2 Non-refereed book chapter or chapter in a compilation book)