Santosh Lamichhane
PhD (Metabolomics)
santosh.lamichhane@utu.fi |
Lipidomics/Metabolomics
Systems medicine
Gut metabolome
Multivariate data analysis
Santosh Lamichhane is Docent in Metabolomics at Department of Life Technologies, University of Turku. He works as a Post-doctoral researcher, at Turku Bioscience Center. Lamichhane's PhD project involved development of metabolomics platform to elucidate the effects of Ploydextrose (synthetic fiber) on activity of the gut microbiota both in vivo and in vitro in the colon. During his PhD Lamichhane visited Bio-system data analysis Group at University of Amsterdam to enhance his skills in Multivariate Data analysis. He completed his Master's in Molecular medicine from Norwegian University of Science and Technology, Trondheim, Norway. During his masters he had been working with cancer cell metabolism, in particular being focused on Breast tumor tissues.
Lamichhane's research interest lies in the interface of human health, diet and gut microbial activity. He wants to connect these dots (health, diet, microbes) by profiling small molecules (termed as metabolites), which circulates in our body. To be very specific Lamichhanes core interest are reflected by following keywords:
- Metabolomics-Metabolites-Small molecules
- Human Nutrition and health
- Pre and Probiotics / Gut Microbiome
- Human intervention study
Relating to Lamichhane's experience, he has spent approximately a decade profiling small molecules in relation to human heath and (or) gut metabolome. He is open to collaborations relating to gut, health, metabolites and microbiome
Metabolomics lecture in Systems biology (SYS21012), Modern biotechnologies and bioinformatics course (BIOT1524), Bioanalytical Techniques (CHEMI6429) at University of Turku.
- Changes in lipids and inflammation in adults with super-refractory status epilepticus on a ketogenic diet (2023)
- Frontiers in Molecular Biosciences
(Refereed journal article or data article (A1)) - Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
(Refereed journal article or data article (A1)) - Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study (2023)
- International Journal of Molecular Sciences
(Refereed journal article or data article (A1)) - Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine (2023)
- Computational and Structural Biotechnology Journal
(Refereed review article in scientific journal (A2)) - Dynamics of the Lipidome in a Colon Simulator (2023)
- Metabolites
(Refereed journal article or data article (A1)) - Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads (2023)
- Environment International
(Refereed journal article or data article (A1)) - Infant gut microbiota and negative and fear reactivity (2023)
- Development and Psychopathology
(Refereed journal article or data article (A1)) - Recent advances towards mass spectrometry-based clinical lipidomics (2023)
- Current Opinion in Chemical Biology
(Refereed review article in scientific journal (A2)) - Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes (2022)
- Cell Reports Medicine
(Refereed journal article or data article (A1)) - Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life (2022)
- Frontiers in Nutrition
(Refereed journal article or data article (A1)) - Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis (2021)
- Schizophrenia Bulletin
(Refereed journal article or data article (A1)) - Deep learning meets metabolomics: a methodological perspective (2021)
- Briefings in Bioinformatics
(Refereed review article in scientific journal (A2)) - Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk (2021)
- Environment International
(Refereed journal article or data article (A1)) - Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations (2021)
- Metabolites
(Refereed review article in scientific journal (A2)) - Systems biology approaches to study lipidomes in health and disease (2021)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
(Refereed review article in scientific journal (A2)) - Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)
- Diabetologia
(Refereed journal article or data article (A1)) - Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes (2020)
- Environment International
(Refereed journal article or data article (A1)) - Circulating metabolites in progression to islet autoimmunity and type 1 diabetes (2019)
- Diabetologia
(Refereed journal article or data article (A1)) - Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)
- Biomolecules
(Refereed journal article or data article (A1)) - Lipidomes in health and disease: Analytical strategies and considerations (2019)
- Trends in Analytical Chemistry
(Refereed journal article or data article (A1))