Jianwei Li
PhD, Group Leader
jianwei.li@utu.fi +358 29 450 2387 +358 54 7696 07 Tykistökatu 6 Turku |
Systems Chemistry; Dynamic Combinatorial Chemistry; Supramolecular Chemistry; Nanomedicine; Biomaterials
Jianwei Li is a Senior Researcher and a group leader at the Medicity Research Laboratory, the University of Turku. Before he started his independent research in September 2016 in Finland, he had obtained his PhD degree (2014) with Prof. Sijbren Otto at the University of Groningen, the Netherlands and worked as a postdoc in the group of Prof. Hagan Bayley in Oxford University, UK. His group aims to play the interface between systems chemistry and materials chemistry for exploring advanced applications in biomedicine.
Molecular Systems Engineering is an emerging field by understanding the fundementals of molecular properties and dynamics in synthetic complex systems, and exploring sophisticated functions for advanced applications in biomedicine, materials and energy. Our laboratory uses the tools of dynamic combinatorial chemistry (DCC), supramolecular chemistry and computer chemistry to fabricate the framework of complex chemical systems, investigates the self-assembly in such systems and uncovers the working principles at molecular level behind them. We have learned that self-assembly can not only direct the formation of beautiful and intriguing structures i.e. catenanes and “Russian-doll”-like supramolecular architectures, but also promote the molecules to make copies of themselves as the living matters in nature. Currently we are trying to extend the board of DCC into the fields of materials science for cancer treatment.
- Quantitative synthesis of dynamic combinatorial macrocycles accelerated by preorganization of AIEgens for live visualization of drug release (2025)
- Cell Reports Physical Science
- Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy (2025)
- Rare Metals
- A molecular container providing supramolecular protection against acetylcholine hydrolysis (2024)
- Organic and Biomolecular Chemistry
- Anchoring Cu2O nanoparticles on g-C3N4 nanosheets for enhanced photocatalytic performance (2024)
- Fuel
- A technical review on characterization methods for structures and properties of emulsion (2024)
- APL materials
- A TICT-AIE activated dual-channel fluorescence-on probe to reveal the dynamics mechanosensing of lipid droplets during ferroptosis (2024)
- Talanta
- Green and controllable synthesis of symmetrical and unsymmetrical difluoromethylated diarylmethanes via a direct bisarylation strategy enabled by an HFIP-B(C6F5)3 adduct (2024)
- Green Chemistry
- Mechanically Active Supramolecular Systems (2024)
- Small Science
- Multifunctional fluorescent probe for simultaneous revealing Cys and ONOO– dynamic correlation in the ferroptosis (2024)
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- Mutualistic Synthesis from Orthogonal Dynamic Covalent Reactions (2024)
- Angewandte Chemie International Edition
- Self-Adaptive Synthesis of Non-Covalent Crosslinkers while Folding Single-Chain Polymers (2024)
- Angewandte Chemie International Edition
- Self-assembly of stabilized droplets from liquid-liquid phase separation for higher-order structures and functions (2024)
- Communications chemistry
- Unveiling chlorine's role: How it shapes the formation and light-activated oxygen dynamics of chlorophenol-derived environmental persistent free radicals (2024)
- Journal of Hazardous Materials
- A Calcination-Free Sol-Gel Method to Prepare TiO2-Based Hybrid Semiconductors for Enhanced Visible Light-Driven Hydrogen Production (2023)
- ChemPlusChem
- Controllable and chemo-selective conversion of sodium sulfinates to disulfides or thiosulfonates by a solvent-free mechanochemical approach (2023)
- Tetrahedron
- Front Cover: A Calcination-Free Sol-Gel Method to Prepare TiO2-Based Hybrid Semiconductors for Enhanced Visible Light-Driven Hydrogen Production (ChemPlusChem 11/2023) (2023)
- ChemPlusChem
- Kinetic control over co-self-assembly using an in situ dynamic covalent reaction resulting in a synergistic chemo-photodynamic therapy (2023)
- Cell Reports Physical Science
- Protocol for preparing dynamic covalent macrocycles for co-delivering genes and drugs to cancer cell lines (2023)
- STAR protocols
- Stimuli-Responsive Codelivery System Self-Assembled from in Situ Dynamic Covalent Reaction of Macrocyclic Disulfides for Cancer Magnetic Resonance Imaging and Chemotherapy (2023)
- ACS Applied Materials and Interfaces
- Using host-guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer (2023)
- Journal of Materials Chemistry B