Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Asiantuntijuusalueet
Single-cell genomics, immunology
Single-cell genomics, immunology
Tutkimusyhteisö tai tutkimusaihe
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biografia
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Tutkimus
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Opetus
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Julkaisut
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics (2020)
- Circulation Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activitiesSingle-cell immune profiling reveals new insights into colorectal cancer (2020)
- Genome Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2020) Immunometabolism: Methods and protocols Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory (2020)
- Nature Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2019)
- DiabetesBriefings in Functional Genomics
- Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease (2019)
- Clinical Epigenetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2019)
- Immunology and Cell BiologyImmunity
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Global and targeted approaches to single-cell transcriptome characterization (2018)
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)



