Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Areas of expertise
Single-cell genomics, immunology
Single-cell genomics, immunology
Research community or research topic
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biography
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Research
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Teaching
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Publications 
5 of 6
- Single-cell RNA-sequencing resolves self-antigen expression during mTEC development (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - A practical guide to single-cell RNA- sequencing for biomedical research and clinical applications (2017)
- Genome MedicineBriefings in Functional Genomics
(A2 Refereed review article in a scientific journal ) - Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malariaGlobal Chromatin State Analysis Reveals Lineage-Specific Enhancers during the Initiation of Human T helper 1 and T helper 2 Cell Polarization (2017)
- Science Immunology
(A1 Refereed original research article in a scientific journal) - Cutting-edge single-cell genomics and modelling in immunology (2016)
- Immunology and Cell BiologyImmunity
(B1 Non-refereed article in a scientific journal) - Single-cell analysis of CD4+T-cell differentiation reveals three major cell states and progressive acceleration of proliferation (2016)
- Genome Biology
(A1 Refereed original research article in a scientific journal) - Single-cell technologies are revolutionizing the approach to rare cells (2016)
- Immunology and Cell BiologyScandinavian Journal of Immunology
(A1 Refereed original research article in a scientific journal) - T cell fate and clonality inference from single-cell transcriptomes (2016)
- Nature Methods
(A1 Refereed original research article in a scientific journal) - From a gene-centric to whole-proteome view of differentiation of T helper cell subsets (2013)
(A1 Refereed original research article in a scientific journal) - (2013)
(A1 Refereed original research article in a scientific journal) - Holistic Systems Biology Approaches to Molecular Mechanisms of Human Helper T Cell Differentiation to Functionally Distinct Subsets (2013)
(A1 Refereed original research article in a scientific journal)
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