A1 Refereed original research article in a scientific journal

Single-cell technologies are revolutionizing the approach to rare cells




AuthorsProserpio V, Lonnberg T

PublisherNATURE PUBLISHING GROUP

Publication year2016

JournalImmunology and Cell Biology

Journal name in sourceIMMUNOLOGY AND CELL BIOLOGY

Journal acronymIMMUNOL CELL BIOL

Volume94

Issue3

First page 225

Last page229

Number of pages5

ISSN0818-9641

DOIhttps://doi.org/10.1038/icb.2015.106(external)


Abstract
In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. These fine-grained analyses have highlighted the great heterogeneity within each cell compartment revealing previously unknown subpopulations of cells. In this review, we analyze how this fast technological evolution has improved our understanding of the biological processes with a particular focus on rare cells of the immune system.



Last updated on 2024-26-11 at 20:52